Evidence map›Paper›PMID 29771293›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2018

Breakthrough Fungal Infections in Patients With Leukemia Receiving Isavuconazole.

Caitlin R Rausch, Adam J DiPippo, Prithviraj Bose, Dimitrios P Kontoyiannis

Abstract read
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Isavuconazole as Primary Antifungal Prophylaxis in Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome: An Open-label, Prospective, Phase 2 Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021
    Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. IDCases · 2025
    Article
  9. A breakthroughFrontiers in cellular and infection microbiology · 2025
    Article
  10. Epidemiology of Invasive Candidiasis.Clinical epidemiology · 2024
    Review
  11. Potential role of broad-spectrum azoles as therapy forMedical mycology case reports · 2023
    Article
  12. Review
  13. Article
  14. What Is New in Pulmonary Mucormycosis?Journal of fungi (Basel, Switzerland) · 2023
    Review
  15. Article
  16. New Perspectives on Antimicrobial Agents: Isavuconazole.Antimicrobial agents and chemotherapy · 2022
    Review
  17. Isavuconazole for COVID-19-Associated Invasive Mold Infections.Journal of fungi (Basel, Switzerland) · 2022
    Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Caitlin R RauschDivision of Pharmacy, The University of Texas MD Anderson Cancer Center, Houston.
Adam J DiPippoDivision of Pharmacy, The University of Texas MD Anderson Cancer Center, Houston.
Prithviraj BoseDepartments of Leukemia, The University of Texas MD Anderson Cancer Center, Houston.
Dimitrios P KontoyiannisInfectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston.

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
NCI NIH HHS P30 CA016672
6 · The paper itself

Abstract

We retrospectively assessed breakthrough invasive fungal infections (b-IFIs) in 100 consecutive patients with leukemia receiving single-agent isavuconazole; 13 had documented b-IFIs (candidiasis in 6, mucormycosis in 4). All b-IFIs were observed in patients with prolonged neutropenia and active leukemia.

Indexed as

AdultAgedAged, 80 and overAntifungal AgentsCandidemiaElectronic Health RecordsFemaleHumansInvasive Fungal InfectionsLeukemiaMaleMiddle AgedNitrilesPyridinesRetrospective StudiesTriazolesAntifungal AgentsisavuconazoleNitrilesPyridinesTriazoles

Identifiers

PMID29771293
PMCPMC6454429

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.