Evidence map›Paper›PMID 29771277›Full record

Trial reportClinical infectious diseases : an official publication of the Infectious Diseases Society of America2018

Effect of Antiretroviral Therapy on Plasma Concentrations of Chloroquine and Desethyl-chloroquine.

Matthew M Ippolito, Jeffrey M Jacobson, Michael M Lederman, Markus Winterberg, Joel Tarning, Theresa A Shapiro, Charles Flexner

Open access · bronzeAbstract readClinical Trial, Phase II
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Dose Optimization of Hydroxychloroquine for Coronavirus Infection 2019: Do Blood Concentrations Matter?Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020
    Article
  3. Article
  4. Health Considerations for HIV-Infected International Travelers.Current infectious disease reports · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 3 countries.

Matthew M IppolitoDivision of Clinical Pharmacology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Jeffrey M JacobsonCenter for Translational AIDS Research, Departments of Medicine and Neuroscience, Temple University Lewis Katz School of Medicine, Philadelphia, Pennsylvania.
Michael M LedermanDivision of Infectious Disease, Department of Medicine, Case Western Reserve University, Cleveland, Ohio.
Markus WinterbergMahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand.
Joel TarningMahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand.
Theresa A ShapiroDivision of Clinical Pharmacology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Charles FlexnerDivision of Clinical Pharmacology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Johns Hopkins Medicine · USCase Western Reserve University · USJohns Hopkins University · USMahidol Oxford Tropical Medicine Research Unit · THNuffield Orthopaedic Centre · GBTemple University · US

Funding

Leadership and Operations Center (LOC), AIDS Clinical Trials Group (ACTG); LOC 1/UM1AI068636 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Joseph J Eron, RAJESH T GANDHI · 2011 to 2026
$1073.1M
AIDS Clinical Trials Group NetworkU01AI068636 · NIAID · SOCIAL AND SCIENTIFIC SYSTEMS, INC. · PI KURITZKES, DANIEL R. · 2006 to 2010
$147.1M
WG3: HIV, Co-infections and Co-morbiditiesP30AI036219 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI Alan David Levine · 1994 to 2026
$50.0M
Case Clinical Trials Unit: Administrative Supplement NOSI AI-20-031.UM1AI069501 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI George Yendewa · 2012 to 2026
$40.4M
Clinical Pharmacology Training ProgramT32GM066691 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Matthew Michael Ippolito · 2003 to 2026
$6.4M
NIAID NIH HHS P30 AI036219NIAID NIH HHS U01 AI068636NIAID NIH HHS UM1 AI068636NIAID NIH HHS UM1 AI069501NIGMS NIH HHS T32 GM066691Wellcome Trust
6 · The paper itself

Abstract

The effect of antiretroviral therapy (ART) on chloroquine and desethyl-chloroquine plasma concentrations was evaluated in clinical trial participants. Concentrations did not differ among participants receiving protease inhibitor-based ART (n = 9), efavirenz-based ART (n = 15), or other ART (n = 8) and those not receiving ART (n = 31). Efavirenz seemed to inhibit chloroquine desethylation.

Indexed as

AdultAlkynesAntimalarialsAnti-Retroviral AgentsAntiretroviral Therapy, Highly ActiveBenzoxazinesChloroquineCyclopropanesDrug InteractionsFemaleHIV InfectionsHumansMalariaMaleMiddle AgedProtease InhibitorsAlkynesAntimalarialsAnti-Retroviral AgentsBenzoxazinesChloroquineCyclopropanesdesethylchloroquineefavirenzProtease Inhibitors

Identifiers

PMID29771277
PMCPMC6206114
OpenAlexW2803352346

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.