ArticleMicrobial genomics2018
Bordetella pertussis population dynamics and phylogeny in Japan after adoption of acellular pertussis vaccines.
Article in Microbial genomics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Pertactin deficiency ofHuman vaccines & immunotherapeutics · 2024Pooled it
- Allele-Skewed HLA-DR Immunopeptidomes ofVaccines · 2026Article
- Co-infection with macrolide-resistant and macrolide-susceptibleASM case reports · 2026Article
- Revisiting Whooping Cough: Global Drivers and Implications of Pertussis Resurgence in the Acellular Vaccine Era.Vaccines · 2025Review
- Vaccine antigen-based genotyping ofMicrobiology spectrum · 2025Article
- Molecular epidemiology and genomic features ofFrontiers in microbiology · 2024Article
- Whole-genome comparison of two same-genotype macrolide-resistant Bordetella pertussis isolates collected in Japan.PloS one · 2024Article
- Review
- Whole-Genome Analysis of Bordetella pertussis MT27 Isolates from School-Associated Outbreaks: Single-Nucleotide Polymorphism Diversity and Threshold of the Outbreak Strains.Microbiology spectrum · 2023Article
- Review
- A comprehensive resource for Bordetella genomic epidemiology and biodiversity studies.Nature communications · 2022Article
- Evolution of Bordetella pertussis in the acellular vaccine era in Norway, 1996 to 2019.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2022Article
- Pertactin-Deficient Bordetella pertussis with Unusual Mechanism of Pertactin Disruption, Spain, 1986-2018.Emerging infectious diseases · 2022Article
- Comparative genomics ofMicrobial genomics · 2022Article
- A Cross-Sectional Study Revealing the Emergence of Erythromycin-ResistantFrontiers in microbiology · 2022Article
- Easy identification of insertion sequence mobilization events in related bacterial strains with ISCompare.G3 (Bethesda, Md.) · 2021Article
- Prevalence and characterization of pertactin deficientVaccine: X · 2021Article
- Pertactin-Deficient Bordetella pertussis, Vaccine-Driven Evolution, and Reemergence of Pertussis.Emerging infectious diseases · 2021Review
- Rapid and simple SNP genotyping for Bordetella pertussis epidemic strain MT27 based on a multiplexed single-base extension assay.Scientific reports · 2021Article
- Pertussis Vaccine Candidate Based on Outer Membrane Vesicles Derived From Biofilm Culture.Frontiers in immunology · 2021Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bordetella pertussis, the causative agent of whooping cough, has experienced a resurgence in the past 15 years, despite the existence of both whole-cell and acellular vaccines. Here, we performed whole genome sequencing analysis of 149 clinical strains, provided by the National Institute of Infectious Diseases (NIID), Japan, isolated in 1982-2014, after Japan became the first country to adopt acellular vaccines against B. pertussis. Additionally, we sequenced 39 strains provided by the Konan Kosei Hospital in Aichi prefecture, Japan, isolated in 2008-2013. The genome sequences afforded insight into B. pertussis genome variability and population dynamics in Japan, and revealed that the B. pertussis population in Japan was characterized by two major clades that divided more than 40 years ago. The pertactin gene was disrupted in about 20 % of the 149 NIID isolates, by either a deletion within the signal sequence (ΔSS) or the insertion of IS element IS481 (prn :: IS481). Phylogeny suggests that the parent clones for these isolates originated in Japan. Divergence dating traced the first generation of the pertactin-deficient mutants in Japan to around 1990, and indicated that strains containing the alternative pertactin allele prn2 may have appeared in Japan around 1974. Molecular clock data suggested that observed fluctuations in B. pertussis population size may have coincided with changes in vaccine usage in the country. The continuing failure to eradicate the disease warrants an exploration of novel vaccine compositions.
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