Observational studyJournal of veterinary internal medicine2018
Fractional excretion of electrolytes in volume-responsive and intrinsic acute kidney injury in dogs: Diagnostic and prognostic implications.
Observational study in Journal of veterinary internal medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 37 citations in OpenAlex.
- Reply to the Commentary: Should Injectable Meloxicam Be Approved for Use in Cats?Journal of veterinary pharmacology and therapeutics · 2026Article
- Preliminary study investigating the role of estimated glomerular filtration rate, proteinuria and hypertension to inform on chronic kidney disease after acute kidney injury.The Journal of small animal practice · 2026Article
- Case Report: Presumed cerebral salt wasting syndrome in a 10-week-old German Shorthaired Pointer.Frontiers in veterinary science · 2025Article
- New-onset organ dysfunction as a screening tool for the identification of sepsis and outcome prediction in dogs with systemic inflammation.Frontiers in veterinary science · 2024Article
- Effect of an Immunomodulatory Feed Additive in Mitigating the Stress Responses in Lactating Dairy Cows to a High Concentrate Diet Challenge.Animals : an open access journal from MDPI · 2022Article
- Article
- Concomitant Infections With Canine Parvovirus Type 2 and Intracellular Tick-Borne Pathogens in Two Puppy Dogs.Frontiers in veterinary science · 2022Article
- Hyperammonemia in azotemic cats.Journal of feline medicine and surgery · 2021Article
- Alterations of Serum Biochemical and Urinary Parameters in a Canine Population before and after Intravenous Contrast Administration.Veterinary sciences · 2021Article
- Calcium and phosphate homeostasis in dogs with newly diagnosed naturally occurring hypercortisolism.Journal of veterinary internal medicine · 2021Article
- Hypertension, retinopathy, and acute kidney injury in dogs: A prospective study.Journal of veterinary internal medicine · 2020Article
- Evaluation of Symmetric Dimethylarginine (SDMA) in Dogs with Acute Pancreatitis.Veterinary sciences · 2020Article
- Urine neutrophil gelatinase-associated lipocalin to diagnose and characterize acute kidney injury in dogs.Journal of veterinary internal medicine · 2020Article
- Urinary Fractional Clearance of Sodium in 8 Healthy Beagle Dogs Fed Normal, Low, or Ultralow Sodium Diets.Veterinary medicine international · 2020Article
- Machine learning for the prediction of volume responsiveness in patients with oliguric acute kidney injury in critical care.Critical care (London, England) · 2019Article
- Fractional excretion of electrolytes in volume-responsive and intrinsic acute kidney injury in dogs: Diagnostic and prognostic implications.Journal of veterinary internal medicine · 2018Observational
- Retrospective Evaluation of Acute Kidney Injury and Its Association With Severity and Outcome in Small Animal Trauma Patients: 387 Cases (2017-2021).Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe value of fractional excretion (FE) of electrolytes to characterize and prognosticate acute kidney injury (AKI) is poorly documented in dogs.
objectivesTo evaluate the diagnostic and prognostic roles of FE of electrolytes in dogs with AKI. ANIMALS: Dogs (n = 135) with AKI treated with standard care (February 2014-December 2016).
methodsProspective study. Clinical and laboratory variables including FE of electrolytes, were measured upon admission. Dogs were graded according to the AKI-IRIS guidelines and grouped according to AKI features (volume-responsive, VR-AKI; intrinsic, I-AKI) and outcome (survivors/non-survivors). Group comparison and regression analyses with hazard ratios (HR) evaluation for I-AKI and mortality were performed. P < .05 was considered significant.
resultsFifty-two of 135 (39%) dogs had VR-AKI, 69/135 (51%) I-AKI and 14/135 (10%) were unclassified. I-AKI dogs had significantly higher FE of electrolytes, for example, FE of sodium (FENa, %) 2.39 (range 0.04-75.81) than VR-AKI ones 0.24 (range 0.01-2.21; P < .001). Overall, case fatality was 41% (55/135). Increased FE of electrolytes were detected in nonsurvivors, for example, FENa 1.60 (range 0.03-75.81) compared with survivors 0.60 (range 0.01-50.45; P = .004). Several risk factors for death were identified, including AKI-IRIS grade (HR = 1.39, P = .002), FE of electrolytes, for example, FENa (HR = 1.03, P < .001), and urinary output (HR = 5.06, P < .001). CONCLUSIONS AND CLINICAL IMPORTANCE: Fractional excretion of electrolytes performed well in the early differentiation between VR-AKI and I-AKI, were related to outcome, and could be useful tools to manage AKI dogs in clinical practice.
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