ArticleObesity surgery2018
Roux-en-Y Gastric Bypass Surgery-Induced Weight Loss and Metabolic Improvements Are Similar in TGR5-Deficient and Wildtype Mice.
Article in Obesity surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 32 citations in OpenAlex.
- Alterations in bile acid kinetics after bariatric surgery in patients with obesity with or without type 2 diabetes.EBioMedicine · 2024Article
- Weight-independent effects of Roux-en-Y gastric bypass surgery on remission of nonalcoholic fatty liver disease in mice.Obesity (Silver Spring, Md.) · 2023Article
- New Mouse Models of Roux-en Y Gastric Bypass and One Anastomosis Gastric Bypass for Type 2 Diabetes.Obesity surgery · 2023Article
- Glucose metabolism after bariatric surgery: implications for T2DM remission and hypoglycaemia.Nature reviews. Endocrinology · 2023Review
- Gastric bypass surgery weight loss-independently induces gut Il-22 release in association with improved glycemic control in obese Zucker fatty rats.Metabolism open · 2023Article
- Regulation of body weight: Lessons learned from bariatric surgery.Molecular metabolism · 2023Review
- Duodenal-jejunal bypass reduces serum ceramidesWorld journal of gastroenterology · 2022Article
- Metabolic Messengers: bile acids.Nature metabolism · 2022Review
- Mechanisms of Weight Loss After Obesity Surgery.Endocrine reviews · 2022Review
- Bile acids, gut microbiota and metabolic surgery.Frontiers in endocrinology · 2022Review
- Bile acids and metabolic surgery.Liver research (Beijing, China) · 2021Review
- Gut-brain communication and obesity: understanding functions of the vagus nerve.The Journal of clinical investigation · 2021Review
- IGFBP-2 partly mediates the early metabolic improvements caused by bariatric surgery.Cell reports. Medicine · 2021Article
- The Phantom Satiation Hypothesis of Bariatric Surgery.Frontiers in neuroscience · 2021Article
- Simulating the Post-gastric Bypass Intestinal Microenvironment Uncovers a Barrier-Stabilizing Role for FXR.iScience · 2020Article
- A sympathetic gut connection drives the metabolic benefits of Roux-en-Y gastric bypass.Cell stress · 2020Article
- TGR5 Signaling in Hepatic Metabolic Health.Nutrients · 2020Review
- Compound 18 Improves Glucose Tolerance in a Hepatocyte TGR5-dependent Manner in Mice.Nutrients · 2020Article
- Farnesoid X receptor contributes to body weight-independent improvements in glycemic control after Roux-en-Y gastric bypass surgery in diet-induced obese mice.Molecular metabolism · 2020Article
- Meal patterns after bariatric surgery in mice and rats.Appetite · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
background and purposeRoux-en-Y gastric bypass surgery (RYGB) remains one of the most effective treatments for obesity and type 2 diabetes. Despite this, the mechanisms through which it acts are still not well understood. Bile acid signaling through the transmembrane G-protein-coupled receptor TGR5 has been shown to have significant effects on metabolism and has recently been reported to be necessary for the full effects of vertical sleeve gastrectomy (VSG), a bariatric surgery with similar effects to RYGB. The goal of the current study is therefore to investigate the role of bile acid signaling through TGR5 to see if it is necessary to obtain the full effects of RYGB.
methodsHigh-fat diet-induced obese TGR5
resultsAlthough the difference in fat mass 20 weeks after surgery between RYGB and sham-operated mice was slightly reduced in TGR5
conclusionsWe conclude that bile acid signaling through TGR5 is not required for the beneficial effects of RYGB in the mouse and that RYGB and VSG may achieve their similar beneficial effects through different mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.