Evidence map›Paper›PMID 29770863›Full record

ReviewCurrent topics in microbiology and immunology

SIV Latency in Macrophages in the CNS.

Lucio Gama, Celina Abreu, Erin N Shirk, Suzanne E Queen, Sarah E Beck, Kelly A Metcalf Pate, Brandon T Bullock, M Christine Zink, Joseph L Mankowski, Janice E Clements

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current topics in microbiology and immunology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
12.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Recovery of Latent HIV-1 from Brain Tissue by Adoptive Cell Transfer in Virally Suppressed Humanized Mice.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2021
    Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Inhibition of the lncRNA SAF drives activation of apoptotic effector caspases in HIV-1-infected human macrophages.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  15. Article
  16. Review
  17. Microglial Cells: The Main HIV-1 Reservoir in the Brain.Frontiers in cellular and infection microbiology · 2019
    Review
  18. Review
  19. Review
  20. Monocytes and Macrophages as Viral Targets and Reservoirs.International journal of molecular sciences · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Lucio GamaDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University, Baltimore, MD, 21205, USA.
Celina AbreuDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University, Baltimore, MD, 21205, USA.
Erin N ShirkDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University, Baltimore, MD, 21205, USA.
Suzanne E QueenDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University, Baltimore, MD, 21205, USA.
Sarah E BeckDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University, Baltimore, MD, 21205, USA.
Kelly A Metcalf PateDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University, Baltimore, MD, 21205, USA.
Brandon T BullockDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University, Baltimore, MD, 21205, USA.
M Christine ZinkDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University, Baltimore, MD, 21205, USA.
Joseph L MankowskiDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University, Baltimore, MD, 21205, USA.
Janice E ClementsDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University, Baltimore, MD, 21205, USA. jclements@jhmi.edu.
Johns Hopkins University · US

Funding

Vaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Richard E. Chaisson · 2012 to 2026
$67.0M
Project 4: Intracellular mechanism of virus persistence in astrocytes/macrophagesP01MH070306 · NIMH · JOHNS HOPKINS UNIVERSITY · PI CLEMENTS, JANICE E · 2004 to 2015
$16.0M
Project !: Differential contribution of resting CD4+ T cells and resident macrophages to viral rebound after antiretroviral treatment interruptionP01AI131306 · NIAID · JOHNS HOPKINS UNIVERSITY · PI MAC GABHANN, FEILIM C · 2017 to 2021
$8.5M
Macrophage Ontogeny and Polarization in HIV/SIV InfectionR01AI127142 · NIAID · JOHNS HOPKINS UNIVERSITY · PI CLEMENTS, JANICE E, GAMA, LUCIO · 2016 to 2020
$3.8M
Novel SIV Model of HANDR01NS077869 · NINDS · JOHNS HOPKINS UNIVERSITY · PI CLEMENTS, JANICE E, MANKOWSKI, JOSEPH L · 2012 to 2016
$3.8M
Eradicating Latent SIV from the CNS by CCR5 InhibitionR01NS089482 · NINDS · JOHNS HOPKINS UNIVERSITY · PI MANKOWSKI, JOSEPH L · 2014 to 2018
$3.8M
Mechanisms of HIV-Induced PNS Disease: The SIV Macaque ModelR01NS055651 · NINDS · JOHNS HOPKINS UNIVERSITY · PI MANKOWSKI, JOSEPH L · 2006 to 2009
$2.5M
Macrophage Polarization in SIV Infection and LatencyR56AI118753 · NIAID · JOHNS HOPKINS UNIVERSITY · PI CLEMENTS, JANICE E · 2015 to 2015
$773k
Virus like particles as a therapeutic vaccine for HIVK01OD021323 · OD · JOHNS HOPKINS UNIVERSITY · PI BECK, SARAH · 2016 to 2020
$651k
NIAID NIH HHS P01 AI131306NIAID NIH HHS P30 AI094189NIAID NIH HHS R01 AI127142NIAID NIH HHS R56 AI118753NIH HHS K01 OD021323NIMH NIH HHS P01 MH070306NINDS NIH HHS R01 NS055651NINDS NIH HHS R01 NS077869NINDS NIH HHS R01 NS089482
6 · The paper itself

Abstract

Lentiviruses infect myeloid cells, leading to acute infection followed by persistent/latent infections not cleared by the host immune system. HIV and SIV are lentiviruses that infect CD4+ lymphocytes in addition to myeloid cells in blood and tissues. HIV infection of myeloid cells in brain, lung, and heart causes tissue-specific diseases that are mostly observed during severe immunosuppression, when the number of circulating CD4+ T cells declines to exceeding low levels. Antiretroviral therapy (ART) controls viral replication but does not successfully eliminate latent virus, which leads to viral rebound once ART is interrupted. HIV latency in CD4+ lymphocytes is the main focus of research and concern when HIV eradication efforts are considered. However, myeloid cells in tissues are long-lived and have not been routinely examined as a potential reservoir. Based on a quantitative viral outgrowth assay (QVOA) designed to evaluate latently infected CD4+ lymphocytes, a similar protocol was developed for the assessment of latently infected myeloid cells in blood and tissues. Using an SIV ART model, it was demonstrated that myeloid cells in blood and brain harbor latent SIV that can be reactivated and produce infectious virus in vitro, demonstrating that myeloid cells have the potential to be an additional latent reservoir of HIV that should be considered during HIV eradication strategies.

Indexed as

Disease Models, AnimalVirus LatencyAnimalsCD4-Positive T-LymphocytesCentral Nervous SystemHIV InfectionsHumansMacaca mulattaMacrophagesSimian Acquired Immunodeficiency SyndromeSimian Immunodeficiency VirusViral Load

Identifiers

PMID29770863
PMCPMC6468993
OpenAlexW2804697890

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.