ArticleVirchows Archiv : an international journal of pathology2018
Predominantly cystic clear cell renal cell carcinoma and multilocular cystic renal neoplasm of low malignant potential form a low-grade spectrum.
Article in Virchows Archiv : an international journal of pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 34 citations in OpenAlex.
- [Cystic renal masses: Active treatment or surveillance? Translation and discussion of a systematic literature review with meta-analysis].Urologie (Heidelberg, Germany) · 2026Article
- A case report: Synchronous occurrence of clear cell renal cell carcinoma and low-malignant-potential multicystic renal tumor within the same kidney.Urology case reports · 2026Article
- [Functional and oncologic outcomes of partial nephrectomy for cystic renal cell carcinoma: A single-center retrospective study].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2024Article
- Clinicopathological characteristics and typing of multilocular cystic renal neoplasm of low malignant potential.World journal of clinical cases · 2024Article
- Review
- Review
- Comparison of partial nephrectomy and radical nephrectomy for cystic renal cell carcinoma: a SEER-based and retrospective study.Scientific reports · 2023Article
- Clear cell renal cell carcinoma with cystic component similar to multilocular cystic renal neoplasm of low malignant potential: a rare pattern of cyst-dependent progression from multilocular cystic renal neoplasm of low malignant potential.Diagnostic pathology · 2023Article
- Comparison of survival between unilocular cystic and purely solid renal cell carcinoma.Scientific reports · 2022Article
- A Comprehensive Commentary on the Multilocular Cystic Renal Neoplasm of Low Malignant Potential: A Urologist's Perspective.Cancers · 2022Article
- Article
- Imaging of Unusual Renal Tumors.Current urology reports · 2019Review
- Prolonged natural history of a cystic renal cell carcinoma: A case report.Indian journal of urology : IJU : journal of the Urological Society of IndiaArticle
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12 authors at 7 institutions in 2 countries.
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Abstract
Multilocular cystic renal cell carcinoma has been recently excluded from clear cell renal cell carcinoma (CCRCC) category and re-designated as multilocular cystic renal neoplasm of low malignant potential (MCRNLMP) due to its uniformly good outcomes. While strict distinction between MCRNLMP from predominantly cystic CCRCC (pc-CCRCC) is being emphasized, the significance of extensive true cystic component in CCRCC has not been investigated. Herein, we analyzed 57 MCRNLMP, 69 pc-CCRCC, and 46 non-cystic CCRCC. There were no statistically significant differences between the three subtypes in age, gender, and laterality. ISUP grades were 1 (73%) or 2 (27%) for MCRNLMP; for pc-CCRCC were 1 (31%), 2 (60%), and 3 (9%); and for non-cystic CCRCC were 1 (9%), 2 (52%), 3 (26%), and 4 (13%). MCRNLMP were either pT stage 1 (91%) or 2 (9%), pT stages for pc-CCRCC were 1 (92.5%), 2 (1.5%), and 3 (6%) and for non-cystic CCRCC were 1 (58.7%), 2 (6.5%), and 3 (34.8%). None of MCRNLMP patients developed recurrences or metastases, and only 1 contralateral kidney tumor and 1 metastasis developed in pc-CCRCC. In contrast, 19 patients with non-cystic CCRCC developed metastases (5-year PFS 58%, CI 38.3-73.5%), and 1 patient died of disease. Monosomy 3 was common in both MCRNLMP (3/3) and pc-CCRCC (6/7). This large series of MCRNLMP confirms its indolent behavior, shows that pc-CCRCC has significantly better prognosis than non-cystic CCRCC and may define the lower grade spectrum of CCRCC. We recommend that the presence and extent of CCRCC cystic component should be documented in the pathology report.
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