Evidence map›Paper›PMID 29770852›Full record

ArticleVirchows Archiv : an international journal of pathology2018

Notch inhibition counteracts Paneth cell death in absence of caspase-8.

M K Jeon, E Kaemmerer, U Schneider, M Schiffer, C Klaus, J Hennings, T Clahsen, T Ackerstaff, M Niggemann, A Schippers and 6 more

Abstract read
PubMed Publisher
In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

M K JeonInstitute of Pathology, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany.
E KaemmererInstitute of Pathology, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany.
U SchneiderInstitute of Pathology, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany.
M SchifferInstitute of Pathology, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany.
C KlausInstitute of Pathology, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany.
J HenningsDepartment of Medicine III, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany.
T ClahsenDepartment of Pediatrics, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany.
T AckerstaffInstitute of Pathology, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany.
M NiggemannInstitute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52056, Aachen, Germany.
A SchippersDepartment of Pediatrics, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany.
T LongerichInstitute of Pathology, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany.
G SellgeDepartment of Medicine III, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany.
C TrautweinDepartment of Medicine III, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany.
N WagnerDepartment of Pediatrics, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany.
C LiedtkeDepartment of Medicine III, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany.
N GasslerInstitute of Pathology, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany. ngassler@ukaachen.de.
RWTH Aachen University · DEKlinikum Braunschweig · DE

Funding

Deutsche Forschungsgemeinschaft GA 785/5-1Deutsche Krebshilfe GA 109313
6 · The paper itself

Abstract

Opposing activities of Notch and Wnt signaling regulate mucosal barrier homeostasis and differentiation of intestinal epithelial cells. Specifically, Wnt activity is essential for differentiation of secretory cells including Wnt3-producing Paneth cells, whereas Notch signaling strongly promotes generation of absorptive cells. Loss of caspase-8 in intestinal epithelium (casp8

Indexed as

AnimalsCaspase 8Cell DeathCell ProliferationDibenzazepinesMaleMetaplasiaMice, Inbred C57BLMice, KnockoutPaneth CellsPermeabilityPhenotypeReceptor, Notch1Secretory PathwayWnt Signaling PathwayCasp8 protein, mouseCaspase 8dibenzazepineDibenzazepinesNotch1 protein, mouseReceptor, Notch1Caspase 8Crohn’s diseaseNotchPaneth cell

Identifiers

PMID29770852
OpenAlexW2803432572

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.