ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2018
Integral bHLH factor regulation of cell cycle exit and RGC differentiation.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 21 citations in OpenAlex.
- Retinal ganglion cells induce stem cell-derived neuroprotection via IL-12 to SCGF-β crosstalk.Stem cell research & therapy · 2025Article
- Notch directs telencephalic development and controls neocortical neuron fate determination by regulating microRNA levels.Development (Cambridge, England) · 2023Article
- Highly distinct genetic programs for peripheral nervous system formation in chordates.BMC biology · 2022Article
- Initiation of Otx2 expression in the developing mouse retina requires a unique enhancer and either Ascl1 or Neurog2 activity.Development (Cambridge, England) · 2021Article
- Cis-regulatory analysis of Onecut1 expression in fate-restricted retinal progenitor cells.Neural development · 2020Article
- Requirements for Neurogenin2 during mouse postnatal retinal neurogenesis.Developmental biology · 2018Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundIn the developing mouse embryo, the bHLH transcription factor Neurog2 is transiently expressed by retinal progenitor cells and required for the initial wave of neurogenesis. Remarkably, another bHLH factor, Ascl1, normally not present in the embryonic Neurog2 retinal lineage, can rescue the temporal phenotypes of Neurog2 mutants.
resultsHere we show that Neurog2 simultaneously promotes terminal cell cycle exit and retinal ganglion cell differentiation, using mitotic window labeling and integrating these results with retinal marker quantifications. We also analyzed the transcriptomes of E12.5 GFP-expressing cells from Neurog2
conclusionsOur data support the hypothesis that Neurog2 acts at the top of a retinal bHLH transcription factor hierarchy. The combined expression levels of these downstream factors are sufficiently induced by ectopic Ascl1 to restore RGC genesis, highlighting the robustness of this gene network during retinal ganglion cell neurogenesis. Developmental Dynamics 247:965-975, 2018. © 2018 Wiley Periodicals, Inc.
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