Evidence map›Paper›PMID 29770360›Full record

ArticlePathogens & immunity2018

Biomarkers Associated with Death After Initiating Treatment for Tuberculosis and HIV in Patients with Very Low CD

Fred R Sattler, Daniel Chelliah, Xingye Wu, Alejandro Sanchez, Michelle A Kendall, Evelyn Hogg, David Lagat, Umesh Lalloo, Valdilea Veloso, Diane V Havlir and 1 more

Open access · diamondAbstract read
In one paragraph

Article in Pathogens & immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. HIV, Tuberculosis, and Food Insecurity in Africa-A Syndemics-Based Scoping Review.International journal of environmental research and public health · 2022
    Article
  4. Article
  5. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 4 countries.

Fred R SattlerKeck School of Medicine of the University of Southern California, Los Angeles, California.
Daniel ChelliahKeck School of Medicine of the University of Southern California, Los Angeles, California.
Xingye WuHarvard School of Public Health, Boston, Massachusetts.
Alejandro SanchezKeck School of Medicine of the University of Southern California, Los Angeles, California.
Michelle A KendallHarvard School of Public Health, Boston, Massachusetts.
Evelyn HoggSocial & Scientific Systems Inc., Silver Springs, Maryland.
David LagatMoi University Clinical Research Center, Eldoret, Kenya.
Umesh LallooEnhancing Care Foundation, Durban University of Technology, Durban, South Africa.
Valdilea VelosoEvandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
Diane V HavlirUniversity of California San Francisco, San Francisco, California.
Alan LandayRush Presbyterian Medical Center, Chicago, Illinois.
University of Southern California · USHarvard University · USDurban University of Technology · ZAFundação Oswaldo Cruz · BRMoi University · KERush University Medical Center · USSocial and Scientific Systems (United States) · USUniversity of California, San Francisco · US

Funding

Leadership and Operations Center (LOC), AIDS Clinical Trials Group (ACTG); LOC 1/UM1AI068636 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Joseph J Eron, RAJESH T GANDHI · 2011 to 2026
$1073.1M
Statistical and Data Management Center (SDMC), AIDS Clinical Trials Group (ACTG)UM1AI068634 · NIAID · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Marlene Ann Cooper, Michael David Hughes · 2011 to 2026
$246.6M
Validation, CLIA and Qualification (VQC): Enhancing the RS ratio as a tool for AIDS Clinical Trial Group (ACTG) tuberculosis trialsUM1AI106701 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Grace M Aldrovandi · 2014 to 2026
$116.8M
San Francisco Vaccine and Prevention UnitUM1AI069496 · NIAID · PUBLIC HEALTH FOUNDATION ENTERPRISES · PI Susan Buchbinder, Diane V Havlir · 2012 to 2026
$30.5M
United States Military HIV Research Program (MHRP) Clinical Trials UnitUM1AI108568 · NIAID · WALTER REED ARMY INSTITUTE OF RESEARCH · PI Julie A. Ake, Merlin L Robb · 2014 to 2026
$24.3M
WOMEN'S HEALTH AGENDAU01AI027673 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI SATTLER, FRED R · 1988 to 2006
$11.2M
NIAID NIH HHS U01 AI027673NIAID NIH HHS UM1 AI068634NIAID NIH HHS UM1 AI068636NIAID NIH HHS UM1 AI069496NIAID NIH HHS UM1 AI106701NIAID NIH HHS UM1 AI108568
6 · The paper itself

Abstract

backgroundThe risk of short-term death for treatment naive patients dually infected with

methodsWe utilized a retrospective case-cohort design among participants of the ACTG A5221 study who had baseline CD4 < 50 cells/mm

resultsThe case-cohort sample was similar to the 282 participants within the parent cohort with CD4 <50 cells/mm

conclusionsUnlike patients only infected with

Indexed as

Adaptive immunityHuman Immunodeficiency VirusInnate immunityMycobacterium tuberculosisNutrition biomarkersPredictors of mortalityTiming of antiretroviral therapy

Identifiers

PMID29770360
PMCPMC5951172
OpenAlexW2802733127

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.