Evidence map›Paper›PMID 29770354›Full record

ArticleBio-protocol2018

3D Co-culture System of Tumor-associated Macrophages and Ovarian Cancer Cells.

Lingli Long, Mingzhu Yin, Wang Min

Open access · greenAbstract read
In one paragraph

Article in Bio-protocol, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 24 citations in OpenAlex.

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  11. The hallmarks of ovarian cancer: Focus on angiogenesis and micro-environment and new models for their characterisation.EJC supplements : EJC : official journal of EORTC, European Organization for Research and Treatment of Cancer ... [et al.] · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Lingli LongCenter for Translational Medicine, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan Rd II, Guangzhou 510080, China.
Mingzhu YinDepartment of Pathology and the Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT06520, USA.
Wang MinCenter for Translational Medicine, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan Rd II, Guangzhou 510080, China.
Sun Yat-sen University · CNYale University · US

Funding

The role of signaling molecule AIP1 in pathological angiogenesisR01HL115148 · NHLBI · YALE UNIVERSITY · PI KYRIAKIDES, THEMIS R · 2013 to 2021
$3.6M
STRESS SIGNALING PATHWAYS LINKING ENDOTHELIAL INJURY TO GRAFT ARTERIOSCLEROSISR01HL109420 · NHLBI · YALE UNIVERSITY · PI POBER, JORDAN S · 2012 to 2020
$3.3M
NHLBI NIH HHS R01 HL109420NHLBI NIH HHS R01 HL115148
6 · The paper itself

Abstract

Ovarian cancer is fairly unique in that ovarian carcinoma cells can detach and spread directly through peritoneal cavity. It has been unclear, however, how detached cancer cells survive in the peritoneum and form spheroid structure. We have recently reported that there is a strong correlation between Tumor-associated macrophages (TAMs)-associated spheroid and clinical pathology of ovarian cancer, and that TAMs promote spheroid formation and tumor growth at early stages of transcoelomic metastasis in orthotopic mouse models. We have established an

Indexed as

3D co-culture systemOvarian cancerSpheroid formationTranscoelomic metastasisTumor-associated macrophage

Identifiers

PMID29770354
PMCPMC5951403
OpenAlexW2801461341

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.