Evidence map›Paper›PMID 29770253›Full record

ArticleSurgical neurology international2018

Simultaneous cerebrospinal fluid and hematologic metastases in a high-grade ependymoma.

Daniel Diaz-Aguilar, Sergei Terterov, Alexander M Tucker, Shaina Sedighim, Rudi Scharnweber, Stephanie Wang, Catherine Merna, Shayan Rahman

Open access · hybridAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Surgical neurology international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.1field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Metastatic Supratentorial Ependymoma: A Case Presentation and Systematic Review of the Literature.Neuropathology : official journal of the Japanese Society of Neuropathology · 2025
    Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Daniel Diaz-AguilarDepartment of Neurosurgery, University of California, David Geffen School of Medicine, California, USA.
Sergei TerterovDepartment of Neurosurgery, University of California, David Geffen School of Medicine, California, USA.
Alexander M TuckerDepartment of Neurosurgery, University of California, David Geffen School of Medicine, California, USA.
Shaina SedighimDepartment of Neurosurgery, University of California, David Geffen School of Medicine, California, USA.
Rudi ScharnweberDepartment of Neurosurgery, University of California, David Geffen School of Medicine, California, USA.
Stephanie WangDepartment of Neurosurgery, University of California, David Geffen School of Medicine, California, USA.
Catherine MernaDepartment of Neurosurgery, University of California, David Geffen School of Medicine, California, USA.
Shayan RahmanDepartment of Neurosurgery, University of California, David Geffen School of Medicine, California, USA.
University of California System · USUniversity of Miami · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEpendymomas are relatively uncommon tumors that constitute about 7% of all primary intracranial neoplasms. Among these, high-grade ependymomas are locally aggressive and recur most commonly at the primary site following resection. Ependymomas are also known to be the one glial neoplasm that tends to frequently metastasize inside and outside the central nervous system (CNS) that complicates workup and management. Metastasis due to surgical manipulation is common and neurosurgeons should be well-versed in the most effective methods to remove these tumors in order to avoid such metastases. CASE DESCRIPTION: Here, we report a case of a 28-year-old female who initially presented with a parenchymal World Health Organization (WHO) grade III anaplastic ependymoma of the occipital lobe without metastasis. After multiple resections, the patient showed no evidence of disease recurrence for 2 years. During follow-up, new metastasis to the frontal lobe as well as to the lung were discovered 2 years after the initial surgery, without recurrence at the tumor's primary site.

conclusionsWhile uncommon, this case demonstrates the possibility for ependymomas to metastasize via cerebrospinal fluid to other locations within the CNS and hematologically to extraneural locations without recurring locally.

Indexed as

Cerebrospinal fluid metastasisependymomahematologic metastasis

Identifiers

PMID29770253
PMCPMC5938895
OpenAlexW2801284287

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.