Evidence map›Paper›PMID 29770146›Full record

Trial reportNeural plasticity2018

Effects of 20 Hz Repetitive Transcranial Magnetic Stimulation on Disorders of Consciousness: A Resting-State Electroencephalography Study.

Fangping He, Min Wu, Fanxia Meng, Yangfan Hu, Jian Gao, Zhongqin Chen, Wangxiao Bao, Kehong Liu, Benyan Luo, Gang Pan

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neural plasticity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03385278 (Effects of Repetitive Transcranial Magnetic Stimulation on the Disorders of Consciousness), which is not on this map. Cited by 41 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 3 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03385278 naunknown statusnot on this map

Effects of Repetitive Transcranial Magnetic Stimulation on the Disorders of Consciousness

TypeinterventionalSponsorFirst Affiliated Hospital of Zhejiang UniversityRan2015 to 2018Enrolled10ConditionsDisorder of ConsciousnessArmsrTMS
3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 3 syntheses or guidelines pooled it, 78 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Fangping HeDepartment of Neurology and Brain Medical Centre, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.ORCID 0000-0002-6180-6054
Min WuDepartment of Neurology and Brain Medical Centre, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.ORCID 0000-0001-8753-0327
Fanxia MengDepartment of Neurology and Brain Medical Centre, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.
Yangfan HuDepartment of Computer Science, Zhejiang University, Hangzhou 310007, China.
Jian GaoDepartment of Rehabilitation, Hangzhou Hospital of Zhejiang Armed Police Corps, Hangzhou 310051, China.
Zhongqin ChenDepartment of Neurology and Brain Medical Centre, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.
Wangxiao BaoDepartment of Neurology and Brain Medical Centre, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.
Kehong LiuDepartment of Rehabilitation, Hangzhou Hospital of Zhejiang Armed Police Corps, Hangzhou 310051, China.
Benyan LuoDepartment of Neurology and Brain Medical Centre and Collaborative Innovation Center for Brain Science, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.ORCID 0000-0002-9892-5778
Gang PanDepartment of Computer Science, Zhejiang University, Hangzhou 310007, China.ORCID 0000-0002-4049-6181
Zhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Repetitive transcranial magnetic stimulation (rTMS) has been proposed as an experimental approach for the treatment of disorders of consciousness (DOC). To date, there has been little research into the use of rTMS in DOC and the therapeutic effects have been variously documented. This study aimed to examine the effects of 20 Hz rTMS on the electroencephalography (EEG) reactivity and clinical response in patients with DOC and to explore the neuromodulatory effects of high-frequency rTMS. In this randomized, sham-controlled, crossover study, real or sham 20 Hz rTMS was applied to the left primary motor cortex (M1) of patients with DOC for 5 consecutive days. Evaluations were blindly performed at the baseline (T0), immediately after the end of the 5 days of treatment (T1) and 1 week after the treatment (T2) using the JFK coma recovery scale-revised (CRS-R) and resting-state EEG. Only one patient, with a history of 2 months of traumatic brain injury, showed long-lasting (T1, T2) behavioral and neurophysiological modifications after the real rTMS stimulation. The 5 remaining patients presented brain reactivity localized at several electrodes, and the EEG modification was not significant. rTMS stimulation may improve awareness and arousal of DOC. Additionally, EEG represents a potential biomarker for the therapeutic efficacy of rTMS. This trial is registered with (NCT03385278).

Indexed as

AdolescentAdultConsciousness DisordersCross-Over StudiesElectroencephalographyFemaleHumansMaleMiddle AgedRestTranscranial Direct Current StimulationTranscranial Magnetic StimulationTreatment Outcome

Identifiers

PMID29770146
PMCPMC5889874
OpenAlexW2792431309

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.