Evidence map›Paper›PMID 29770136›Full record

ArticleFrontiers in immunology2018

CD3ε Expression Defines Functionally Distinct Subsets of Vδ1 T Cells in Patients With Human Immunodeficiency Virus Infection.

Pádraic J Dunne, Christina O Maher, Michael Freeley, Katie Dunne, Andreea Petrasca, Judy Orikiiriza, Margaret R Dunne, Derval Reidy, Siobhan O'Dea, Aisling Loy and 5 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
  3. IL-21-dependent Ly6CCell death discovery · 2025
    Article
  4. Severity of critical illness correlates with CD3-low expression on iNKT-cells among septic surgical patients.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024
    Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Renal Cell Carcinoma-Infiltrating CD3Current issues in molecular biology · 2021
    Article
  10. Review
  11. Review
  12. Protective Role ofJournal of immunology research · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Pádraic J DunneDiscipline of Immunology, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
Christina O MaherDiscipline of Immunology, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
Michael FreeleyDiscipline of Clinical Medicine, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
Katie DunneDiscipline of Clinical Microbiology, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
Andreea PetrascaDiscipline of Immunology, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
Judy OrikiirizaDiscipline of Immunology, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
Margaret R DunneDiscipline of Immunology, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
Derval ReidyGenitourinary Infectious Diseases Department, St. James's Hospital, Dublin, Ireland.
Siobhan O'DeaGenitourinary Infectious Diseases Department, St. James's Hospital, Dublin, Ireland.
Aisling LoyGenitourinary Infectious Diseases Department, St. James's Hospital, Dublin, Ireland.
Jim WooGenitourinary Infectious Diseases Department, St. James's Hospital, Dublin, Ireland.
Aideen LongDiscipline of Clinical Medicine, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
Thomas R RogersDiscipline of Clinical Microbiology, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
Fiona MulcahyGenitourinary Infectious Diseases Department, St. James's Hospital, Dublin, Ireland.
Derek G DohertyDiscipline of Immunology, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
Trinity College Dublin · IESt. James's Hospital · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human γδ T cells expressing the Vδ1 T cell receptor (TCR) recognize self and microbial antigens and stress-inducible molecules in a major histocompatibility complex-unrestricted manner and are an important source of innate interleukin (IL)-17. Vδ1 T cells are expanded in the circulation and intestines of patients with human immunodeficiency virus (HIV) infection. In this study, we show that patients with HIV have elevated frequencies, but not absolute numbers, of circulating Vδ1 T cells compared to control subjects. This increase was most striking in the patients with

Indexed as

Gene ExpressionHIV-1BiomarkersCandidiasisCD3 ComplexCoinfectionCytokinesFemaleHIV InfectionsHumansImmunophenotypingLymphocyte CountMaleReceptors, Antigen, T-Cell, gamma-deltaT-Lymphocyte SubsetsBiomarkersCD3 ComplexCD3E protein, humanCytokinesReceptors, Antigen, T-Cell, gamma-deltaCD3εflow cytometryhuman immunodeficiency virusinterleukin-17programmed death-1Vδ1 T cells

Identifiers

PMID29770136
PMCPMC5940748
OpenAlexW2800223205

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.