ArticleFrontiers in neurology2018
Clinical Application of Epilepsy Genetics in Africa: Is Now the Time?
Article in Frontiers in neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Social stigma, genetic services, and South Africa: is testing taboo?Journal of community genetics · 2026Review
- Personalized care of paediatric drug-resistant epilepsy in Africa: A single-centre pilot study utilizing mobile health and genetic testing.Developmental medicine and child neurology · 2026Observational
- Exome sequencing in Nigerian children with early-onset epilepsy syndromes.Epilepsia open · 2025Article
- Trio exome analysis is a valuable tool for genetic diagnosis of epilepsy in Mali.Genetics in medicine open · 2025Article
- Epilepsy grand challenge 2025.Frontiers in neurology · 2025Article
- Clinical signatures of genetic epilepsies precede diagnosis in electronic medical records of 32,000 individuals.Genetics in medicine : official journal of the American College of Medical Genetics · 2024Article
- Epilepsy in rural South Africa: Patient experiences and healthcare challenges.Epilepsia open · 2024Article
- Response to: 'Methodological challenges for conducting case control studies to investigate the association between onchocerciasis and epilepsy including nodding syndrome'.Brain communications · 2024Article
- Epilepsy in Africa: a multifaceted perspective on diagnosis, treatment, and community support.Annals of medicine and surgery (2012) · 2024Article
- Genetic profile of progressive myoclonic epilepsy in Mali reveals novel findings.Frontiers in neurology · 2024Article
- Case report: Novel variants cause developmental and epileptic encephalopathy in three unrelated families from Mali.Frontiers in genetics · 2024Article
- Unlocking the hidden burden of epilepsy in Africa: Understanding the challenges and harnessing opportunities for improved care.Health science reports · 2023Article
- The Potential Mechanism of Cannabidiol (CBD) Treatment of Epilepsy in Pentetrazol (PTZ) Kindling Mice Uncovered by Multi-Omics Analysis.Molecules (Basel, Switzerland) · 2023Article
- Status of epilepsy in the tropics: An overlooked perspective.Epilepsia open · 2023Review
- Epidemiological, clinical and radiological characteristics of people with neurocysticercosis in Tanzania-A cross-sectional study.PLoS neglected tropical diseases · 2022Article
- An aqueous extract of Syzygium cumini protects against kainate-induced status epilepticus and amnesia: evidence for antioxidant and anti-inflammatory intervention.Metabolic brain disease · 2022Article
- Characteristics of people with epilepsy in three Eastern African countries - a pooled analysis.BMC neurology · 2022Article
- Voltage Gated Sodium Channel Genes in Epilepsy: Mutations, Functional Studies, and Treatment Dimensions.Frontiers in neurology · 2021Review
- Magnetic Resonance Imaging Findings in Childhood Epilepsy at a Tertiary Hospital in Kenya.Frontiers in neurology · 2021Article
- Epilepsy Research in Mali: A Pilot Pharmacokinetics Study on First-Line Antiepileptic Drug Treatment.Journal of epilepsy research · 2020Article
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Over 80% of people with epilepsy live in low- to middle-income countries where epilepsy is often undiagnosed and untreated due to limited resources and poor infrastructure. In Africa, the burden of epilepsy is exacerbated by increased risk factors such as central nervous system infections, perinatal insults, and traumatic brain injury. Despite the high incidence of these etiologies, the cause of epilepsy in over 60% of African children is unknown, suggesting a possible genetic origin. Large-scale genetic and genomic research in Europe and North America has revealed new genes and variants underlying disease in a range of epilepsy phenotypes. The relevance of this knowledge to patient care is especially evident among infants with early-onset epilepsies, where early genetic testing can confirm the diagnosis and direct treatment, potentially improving prognosis and quality of life. In Africa, however, genetic epilepsies are among the most under-investigated neurological disorders, and little knowledge currently exists on the genetics of epilepsy among African patients. The increased diversity on the continent may yield unique, important epilepsy-associated genotypes, currently absent from the North American or European diagnostic testing protocols. In this review, we propose that there is strong justification for developing the capacity to offer genetic testing for children with epilepsy in Africa, informed mostly by the existing counseling and interventional needs. Initial simple protocols involving well-recognized epilepsy genes will not only help patients but will give rise to further clinically relevant research, thus increasing knowledge and capacity.
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