ArticlePaediatrics & child health2018
Combined deficiencies of 25-hydroxyvitamin D and anemia in preschool children with severe early childhood caries: A case-control study.
Article in Paediatrics & child health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 5 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 5 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Association Between Iron Deficiency Anemia and Dental Caries in Children: A Systematic Umbrella Meta-Analysis.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2025Pooled it
- The Association Between Vitamin D and Early Childhood Caries: A Systematic Review and Meta-Analysis.Oral health & preventive dentistry · 2024Pooled it
- Correlation between vitamin D levels in serum and the risk of dental caries in children: a systematic review and meta-analysis.BMC oral health · 2023Pooled it
- Iron deficiency and early childhood caries: a systematic review and meta-analysis.Chinese medical journal · 2021Pooled it
- Early Childhood Caries in Indigenous Communities.Pediatrics · 2021Guideline
- Review
- Article
- Iron Deficiency Anemia and Its Impact on Oral Health-A Literature Review.Dentistry journal · 2024Review
- Iron Deficiency Anemia and Dental Caries: A Systematic Review and Meta-Analysis.Global pediatric health · 2024Article
- The antimicrobial effect of different vitamin D compounds onJournal of oral microbiology · 2024Article
- Iron deficiency anemia associated factors and early childhood caries in Qingdao.BMC oral health · 2022Article
- The Association between Standardized Serum 25-HydroxyvitaminInternational journal of clinical practice · 2022Article
- Ferumoxytol Nanoparticles Target Biofilms Causing Tooth Decay in the Human Mouth.Nano letters · 2021Article
- The Most Common Vitamin D Receptor Polymorphisms (Children (Basel, Switzerland) · 2021Review
- Review
- Salivary Microbiome Variation in Early Childhood Caries of Children 3-6 Years of Age and Its Association With Iron Deficiency Anemia and Extrinsic Black Stain.Frontiers in cellular and infection microbiology · 2021Article
- Vitamin D Deficiency and Oral Health: A Comprehensive Review.Nutrients · 2020Review
- The Burden of Early Childhood Caries in Canadian Children and Associated Risk Factors.Frontiers in public health · 2019Review
- Untreated caries and serum vitamin D levels in children and youth of the United States: NHANES 2013-2014.Brazilian dental journalArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSevere early childhood caries (S-ECC) is common and has adverse affects on children's health. Children with S-ECC have been shown to have anemia or vitamin D deficiency. No studies have assessed the presence of combined deficiencies with S-ECC. The purpose of our study was to examine whether those with S-ECC had a higher prevalence of combined anemia and low 25-hydroxyvitamin D (25(OH)D) compared to controls. Covariates associated with elevated parathyroid hormone (PTH), previously noted in S-ECC, were examined.
methodsThis is a re-analyses of a previously described cross-sectional case-control study; data were collected between 2009 and 2011. Children with S-ECC were recruited on the day of dental surgery and controls from the community. Blood was drawn for complete blood count, ferritin, 25(OH)D and PTH. Families completed a questionnaire.
resultsA total of 266 children participated (S-ECC n=144); the mean age was 40.8 ± 14.1 months. Children with S-ECC were more likely to have low 25(OH)D, hemoglobin, elevated PTH or iron-deficiency anemia compared to controls. Significant differences between groups were seen for a combined deficiency of low hemoglobin (<110 g/L)
conclusionsCombined deficiencies of vitamin D and anemia are more prevalent in children with S-ECC; the etiology remains unclear. A detailed diet history is key in those with S-ECC to assess risks for deficiencies.
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