Evidence map›Paper›PMID 29769742›Full record

ArticleActa pharmacologica Sinica2018

Modified citrus pectin inhibited bladder tumor growth through downregulation of galectin-3.

Tian Fang, Dan-Dan Liu, He-Ming Ning, Dan Liu, Jing-Ya Sun, Xiao-Jing Huang, Yu Dong, Mei-Yu Geng, Shi-Feng Yun, Jun Yan and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Acta pharmacologica Sinica, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 64 citations in OpenAlex.

  1. Review
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  11. Clinical significance of galectin-3 expression in urinary bladder carcinoma.The Journal of international medical research · 2023
    Article
  12. Article
  13. Review
  14. An Overview of Antitumour Activity of Polysaccharides.Molecules (Basel, Switzerland) · 2022
    Review
  15. Review
  16. MG-International journal of molecular sciences · 2022
    Article
  17. Review
  18. Review
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 1 country.

Tian FangDepartment of Comparative Medicine, Jinling Hospital, Clinical School of Medical College of Nanjing University, Nanjing, 210002, China.
Dan-Dan LiuShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
He-Ming NingShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Dan LiuState Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animals for Disease Study, Model Animal Research Center of Nanjing University, Nanjing, 210061, China.
Jing-Ya SunShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Xiao-Jing HuangState Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animals for Disease Study, Model Animal Research Center of Nanjing University, Nanjing, 210061, China.
Yu DongShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Mei-Yu GengShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Shi-Feng YunDepartment of Comparative Medicine, Jinling Hospital, Clinical School of Medical College of Nanjing University, Nanjing, 210002, China. yunshifeng1@163.com.
Jun YanState Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animals for Disease Study, Model Animal Research Center of Nanjing University, Nanjing, 210061, China. yanjun@nju.edu.cn.
Rui-Min HuangShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. rmhuang@simm.ac.cn.
Nanjing University · CNChinese Academy of Sciences · CNModel Animal Research Center · CNShanghai Institute of Materia Medica · CNShanghaiTech University · CNShanghai University · CNUniversity of Chinese Academy of Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Modified citrus pectin (MCP) is a carbohydrate enriched complex, which has been implicated in cancer treatment and prevention. However, the effects of MCP on urinary bladder cancer (UBC) are unknown. In this study, MCP was first tested in T24 and J82 human UBC cells and showed the inhibition of cell viability by the sulforhodamine B (SRB) assay. The MCP-treated UBC cells exhibited G

Indexed as

Down-RegulationAnimalsAntineoplastic AgentsApoptosisBlood ProteinsCaspase 3Cell Line, TumorG2 Phase Cell Cycle CheckpointsGalectin 3GalectinsHumansMaleMice, NudePectinsUrinary Bladder NeoplasmsAntineoplastic AgentsBlood ProteinsCASP3 protein, humanCasp3 protein, mouseCaspase 3citrus pectinGalectin 3GalectinsLGALS3 protein, humanLgals3 protein, mousePectinscell survivalgalectin-3modified citrus pectinurinary bladder cancerxenograft

Identifiers

PMID29769742
PMCPMC6289393
OpenAlexW2804088150

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.