ArticleNature2018
Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host.
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In one paragraph
Article in Nature, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 271 papers.
0numbers the graph read from it
0cells of the map it votes in
271citing papers in PubMed
25.5field-weighted citation impact, top 1% of its field
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
271 citing papers in PubMed, 398 citations in OpenAlex.
- Trial
- Effects of IL-1β inhibition on anemia and clonal hematopoiesis in the randomized CANTOS trial.Blood advances · 2023Trial
- HIV is associated with an increased risk of age-related clonal hematopoiesis among older adults.Nature medicine · 2021Trial
- Myeloid reprogramming generates myeloid-derived activating cells to potentiate radiotherapy and suppress metastasis.Cancer cell · 2026Article
- Type 1 interferon perturbates clonal competition by reshaping human blood development.Nature genetics · 2026Article
- Stromal cell senescence augments haematopoietic cell fitness in clonal haematopoiesis.Nature cell biology · 2026Article
- The silent pharmacist: Harnessing the gut microbiome to improve therapy in hematologic malignancies.Translational oncology · 2026Review
- Clonal Hematopoiesis in Colorectal Cancer: Mechanisms and Implications.Cancer medicine · 2026Review
- Article
- Inflammatory signatures in the spectrum of myeloid diseases.HemaSphere · 2026Article
- A 2026 update on myelodysplastic neoplasms: current state, challenges and future directions.Nature reviews. Clinical oncology · 2026Review
- Clonal Hematopoiesis and Gut Microbiota-Derived TMAO as Candidate Amplifiers of Cardiovascular Inflammation: The CHIDT Hypothesis.Antioxidants (Basel, Switzerland) · 2026Review
- Association of infection frequency and incident clonal hematopoiesis of indeterminant potential.Experimental hematology · 2026Article
- Ligature-induced periodontitis promotesHaematologica · 2026Article
- Intratumoral microbiota in cancer: molecular mechanism and therapeutic strategies.Molecular biomedicine · 2026Review
- Leveraging Dietary Interventions to Benefit Patients with Hematologic Malignancies and Clonal Hematopoiesis.Nutrients · 2026Review
- Stromal Gasdermin D-mediated Pyroptosis Drives Maladaptive CD4bioRxiv : the preprint server for biology · 2026Article
- Inflammageing and clonal haematopoiesis interplay and their impact on human disease.Nature reviews. Molecular cell biology · 2026Review
- Novel and emerging therapeutic strategies for clonal hematopoiesis.Haematologica · 2026Review
- TET1 deficiency amplifies macrophage inflammatory signaling associated with Crohn's disease.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Article
211 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
31 authors at 8 institutions in 3 countries.
Marlies Meisel *Department of Medicine, University of Chicago, Chicago, IL, USA.
Reinhard Hinterleitner *Department of Medicine, University of Chicago, Chicago, IL, USA.
Alain PacisDepartment of Genetics, CHU Sainte-Justine Research Center, Montreal, Quebec, Canada.
Li ChenDepartment of Medicine, University of Chicago, Chicago, IL, USA.
Zachary M EarleyDepartment of Medicine, University of Chicago, Chicago, IL, USA.
Toufic MayassiDepartment of Medicine, University of Chicago, Chicago, IL, USA.
Joseph F PierreDepartment of Medicine, University of Chicago, Chicago, IL, USA.
Jordan D ErnestDepartment of Medicine, University of Chicago, Chicago, IL, USA.
Heather J GalipeauFarncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
Nikolaus ThuilleTranslational Cell Genetics, Department for Pharmacology and Genetics, Medical University of Innsbruck, Innsbruck, Austria.
Romain BouziatDepartment of Medicine, University of Chicago, Chicago, IL, USA.
Manuel BuscarletResearch Centre, Hôpital Maisonneuve-Rosemont, Montreal, Quebec, Canada.
Daina L RingusDepartment of Medicine, University of Chicago, Chicago, IL, USA.
Yitang WangDepartment of Pathology and Pediatrics, University of Chicago, Chicago, IL, USA.
Ye LiDepartment of Pathology and Pediatrics, University of Chicago, Chicago, IL, USA.
Vu DinhDepartment of Medicine, University of Chicago, Chicago, IL, USA.
Sangman M KimDepartment of Medicine, University of Chicago, Chicago, IL, USA.
Benjamin D McDonaldDepartment of Medicine, University of Chicago, Chicago, IL, USA.
Matthew A ZurenskiDepartment of Medicine, University of Chicago, Chicago, IL, USA.
Mark W MuschDepartment of Medicine, University of Chicago, Chicago, IL, USA.
Glaucia C FurtadoImmunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Sergio A LiraImmunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Gottfried BaierTranslational Cell Genetics, Department for Pharmacology and Genetics, Medical University of Innsbruck, Innsbruck, Austria.
Eugene B ChangDepartment of Medicine, University of Chicago, Chicago, IL, USA.
A Murat ErenDepartment of Medicine, University of Chicago, Chicago, IL, USA.
Christopher R WeberDepartment of Pathology and Pediatrics, University of Chicago, Chicago, IL, USA.
Lambert BusqueResearch Centre, Hôpital Maisonneuve-Rosemont, Montreal, Quebec, Canada.
Lucy A GodleyDepartment of Medicine, University of Chicago, Chicago, IL, USA.
Elena F VerdúFarncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
Luis B BarreiroDepartment of Genetics, CHU Sainte-Justine Research Center, Montreal, Quebec, Canada.
Bana JabriDepartment of Medicine, University of Chicago, Chicago, IL, USA. bjabri@bsd.uchicago.edu.
University of Chicago · USHôpital Maisonneuve-Rosemont · CAIcahn School of Medicine at Mount Sinai · USUniversité de Montréal · CAInnsbruck Medical University · ATMcMaster University · CAPopulation Health Research Institute · CAUniversität Innsbruck · AT
Funding
VIRAL ONCOLOGY CORE FACILITYP30CA014599 · NCI · UNIVERSITY OF CHICAGO · PI MARK W. LINGEN · 1985 to 2026
$122.1MULTRASTRUCTURE AND CYTOMORPHOLOGY COREP30DK042086 · NIDDK · UNIVERSITY OF CHICAGO · PI LIU, CAMBRIAN YANGSHAO · 1990 to 2025
$29.8MTHE ROLE OF ICSBP IN MUCOSAL IMMUNE RESPONSEP01DK072201 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HARPAZ, NOAM · 2006 to 2015
$14.6MINTERDISCIPLINARY TRAINING PROGRAM IN IMMUNOLOGYT32AI007090 · NIAID · UNIVERSITY OF CHICAGO · PI Peter Aidan Savage · 1985 to 2026
$11.7MInnate and adaptive immunity in celiac diseaseR01DK067180 · NIDDK · UNIVERSITY OF CHICAGO · PI JABRI, BANA · 2005 to 2024
$8.5MMechanisms associated with flares and remission in colitisR01DK110352 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI LIRA, SERGIO A. · 2017 to 2025
$5.1MGraduate Program in Biophysical Sciences at the University of Chicago - Renewal 0T32EB009412 · NIBIB · UNIVERSITY OF CHICAGO · PI ENGEL, GREGORY S, SOSNICK, TOBIN R · 2009 to 2023
$4.9MMolecular pathogenesis of intestinal serrated polypsR01CA161373 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI LIRA, SERGIO A. · 2011 to 2020
$3.7MNovel role and function of Paneth cell PYY in anti-fungal innate immunityF32DK105728 · NIDDK · UNIVERSITY OF CHICAGO · PI PIERRE, JOSEPH F · 2015 to 2015
$54kAustrian Science Fund FWF P 30324Austrian Science Fund FWF P 31383NCI NIH HHS P30 CA014599NCI NIH HHS R01 CA161373NIAID NIH HHS T32 AI007090NIBIB NIH HHS T32 EB009412NIDDK NIH HHS F32 DK105728NIDDK NIH HHS P01 DK072201NIDDK NIH HHS P30 DK042086NIDDK NIH HHS R01 DK067180NIDDK NIH HHS R01 DK110352NIH HHS F32 DK105728-01A1
Abstract
Somatic mutations in tet methylcytosine dioxygenase 2 (TET2), which encodes an epigenetic modifier enzyme, drive the development of haematopoietic malignancies
Indexed as
Asymptomatic DiseasesBacterial Physiological PhenomenaCell ProliferationAnimalsBacterial InfectionsDioxygenasesDNA-Binding ProteinsFemaleGerm-Free LifeInflammationInterleukin-6Intestinal MucosaLactobacillusLeukemiaMaleMiceDioxygenasesDNA-Binding ProteinsInterleukin-6Proto-Oncogene ProteinsTet2 protein, mouseTlr2 protein, mouseToll-Like Receptor 2
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.