Evidence map›Paper›PMID 29769725›Full record

ArticleNature2018

Mxra8 is a receptor for multiple arthritogenic alphaviruses.

Rong Zhang, Arthur S Kim, Julie M Fox, Sharmila Nair, Katherine Basore, William B Klimstra, Rebecca Rimkunas, Rachel H Fong, Hueylie Lin, Subhajit Poddar and 4 more

Abstract read
In one paragraph

Article in Nature, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 306 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
306citing papers in PubMed, 2 pooled it
41.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

306 citing papers in PubMed, 2 syntheses or guidelines pooled it, 430 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Overview of Chikungunya Virus Epidemiology, Biology, and Pathogenesis.Methods in molecular biology (Clifton, N.J.) · 2027
    Review
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  6. Review
  7. Article
  8. Article
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  15. Article
  16. Microbiology spectrum · 2026
    Article
  17. Article
  18. Review
  19. Article
  20. Article

246 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Rong ZhangDepartment of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
Arthur S KimDepartment of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
Julie M FoxDepartment of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
Sharmila NairDepartment of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
Katherine BasoreDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, USA.
William B KlimstraCenter for Vaccine Research, University of Pittsburgh, Pittsburgh, PA, USA.
Rebecca RimkunasIntegral Molecular Inc., Philadelphia, PA, USA.
Rachel H FongIntegral Molecular Inc., Philadelphia, PA, USA.
Hueylie LinDepartment of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
Subhajit PoddarDepartment of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
James E CroweVanderbilt Vaccine Center, Department of Pediatrics and Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
Benjamin J DoranzIntegral Molecular Inc., Philadelphia, PA, USA.
Daved H FremontDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, USA.
Michael S DiamondDepartment of Medicine, Washington University School of Medicine, Saint Louis, MO, USA. diamond@wusm.wustl.edu.
Washington University in St. Louis · USIntegral Molecular (United States) · USUniversity of Pittsburgh · USVanderbilt University Medical Center · US

Funding

Molecular Mechanisms of Eastern Equine Encephalitis Virus PathogenesisR01AI095436 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLIMSTRA, WILLIAM B · 2012 to 2022
$4.5M
Chikungunya Virus Replication and PathogenesisR01AI123348 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DERMODY, TERENCE S., DIAMOND, MICHAEL S · 2016 to 2020
$3.7M
Structural and functional basis of ultra potent CHKV neutralization by human mAbsR01AI114816 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CROWE, JAMES E, DIAMOND, MICHAEL S · 2015 to 2019
$3.7M
NIAID NIH HHS R01 AI095436NIAID NIH HHS R01 AI114816NIAID NIH HHS R01 AI123348
6 · The paper itself

Abstract

Arthritogenic alphaviruses comprise a group of enveloped RNA viruses that are transmitted to humans by mosquitoes and cause debilitating acute and chronic musculoskeletal disease

Indexed as

3T3 CellsAnimalsAntibodies, BlockingChikungunya virusChondrocytesCRISPR-Cas SystemsFibroblastsHumansImmunoglobulinsMaleMembrane ProteinsMiceMuscle, SkeletalO'nyong-nyong VirusOsteoblastsReceptors, FcAntibodies, BlockingImmunoglobulinsMembrane ProteinsMxra8 protein, mouseReceptors, FcReceptors, Virus

Identifiers

PMID29769725
PMCPMC5970976
OpenAlexW2803841447

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.