ArticleNature2018
Bystander CD8
Abstract readComparative Study
In one paragraph
Article in Nature, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 924 papers.
0numbers the graph read from it
0cells of the map it votes in
924citing papers in PubMed
50.9field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
924 citing papers in PubMed, 1,350 citations in OpenAlex.
- 4-1BBCell reports. Medicine · 2025Trial
- Continuous replenishment of the dysfunctional CD8 T cell axis is associated with response to chemoimmunotherapy in advanced breast cancer.Cell reports. Medicine · 2025Trial
- Inhibitory receptor profiles for joint prediction of benefit and toxicity in immune checkpoint blockade.iScience · 2026Review
- T cell immunomonitoring: a comparative analysis of traditional and novel methods to quantify and characterize human antigen-specific T cells.Nature protocols · 2026Review
- Entering the Age of Specificity in T Cell Immunity.Immunological reviews · 2026Review
- Intratumoral T cell activation kills tumors regardless of T cell specificity.Nature immunology · 2026Article
- CD39 on CD8European journal of immunology · 2026Review
- Efficient generation of human cDC1-like cells to detect and enhance tumor-reactive T cells via CD4Cell reports methods · 2026Article
- Impaired regulation by purinergic signaling axis contributes to CD8+ T cell dysregulation in STAT3 gain of function.JCI insight · 2026Article
- Anti-CTLA-4 antibody potentiates the antitumor effect of armed oncolytic virus OVM18 via enhancing intratumoral IL-18R1Journal for immunotherapy of cancer · 2026Article
- HBsAg-tagged tumour vaccine system eliminates solid tumours through virus-specific memory T cells.Nature biomedical engineering · 2026Article
- CX3CR1⁺ CD8⁺ cytotoxic T cells drive tumor killing in esophageal squamous cell carcinoma during neoadjuvant therapy.Nature communications · 2026Article
- Tumor-distal mediastinal lymph nodes harbor tumor-related progenitor exhausted T cells in lung cancer after neoadjuvant chemoimmunotherapy.Cell reports. Medicine · 2026Article
- Persistent cytolytic CD8Cell reports. Medicine · 2026Article
- [Phenotypic and functional changes in endogenous T cells during the bystander effect in different disease states of lymphomas treated with CD19-targeted chimeric antigen receptor T cells].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2026Article
- Cell surface ADGRG1 and CD86 expression identifies antitumor CD4Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- TSTScope Unifies Single-Cell Multi-Omics to Identify Functional T Cell States Predictive of Immunotherapy Response.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Decoding T cell exhaustion in the tumour microenvironment.Experimental & molecular medicine · 2026Review
- Identification of a distinct cluster of LY6EBritish journal of cancer · 2026Article
- Single-nucleus multimodal spatial transcriptomics reveals spatial colocalization of neoantigen-expressing tumor cells and cognate T cells.Nature biotechnology · 2026Article
864 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
32 authors at 6 institutions in 1 country.
Yannick SimoniAgency for Science, Technology and Research (A*STAR), Singapore Immunology Network (SIgN), Singapore, Singapore. yannick_simoni@immunol.a-star.edu.sg.
Etienne BechtAgency for Science, Technology and Research (A*STAR), Singapore Immunology Network (SIgN), Singapore, Singapore.
Michael FehlingsAgency for Science, Technology and Research (A*STAR), Singapore Immunology Network (SIgN), Singapore, Singapore.
Chiew Yee LohAgency for Science, Technology and Research (A*STAR), Singapore Immunology Network (SIgN), Singapore, Singapore.
Si-Lin KooDivision of Medical Oncology, National Cancer Centre Singapore (NCCS), Singapore, Singapore.
Karen Wei Weng TengAgency for Science, Technology and Research (A*STAR), Singapore Immunology Network (SIgN), Singapore, Singapore.
Joe Poh Sheng YeongAgency for Science, Technology and Research (A*STAR), Singapore Immunology Network (SIgN), Singapore, Singapore.
Rahul NaharAgency for Science, Technology and Research (A*STAR), Genome Institute of Singapore (GIS), Singapore, Singapore.
Tong ZhangAgency for Science, Technology and Research (A*STAR), Genome Institute of Singapore (GIS), Singapore, Singapore.
Hassen KaredAgency for Science, Technology and Research (A*STAR), Singapore Immunology Network (SIgN), Singapore, Singapore.
Kaibo DuanAgency for Science, Technology and Research (A*STAR), Singapore Immunology Network (SIgN), Singapore, Singapore.
Nicholas AngAgency for Science, Technology and Research (A*STAR), Singapore Immunology Network (SIgN), Singapore, Singapore.
Michael PoidingerAgency for Science, Technology and Research (A*STAR), Singapore Immunology Network (SIgN), Singapore, Singapore.
Yin Yeng LeeAgency for Science, Technology and Research (A*STAR), Genome Institute of Singapore (GIS), Singapore, Singapore.
Anis LarbiAgency for Science, Technology and Research (A*STAR), Singapore Immunology Network (SIgN), Singapore, Singapore.
Alexis J KhngAgency for Science, Technology and Research (A*STAR), Genome Institute of Singapore (GIS), Singapore, Singapore.
Emile TanDepartment of Colorectal Surgery, Singapore General Hospital, Singapore, Singapore.
Cherylin FuDepartment of Colorectal Surgery, Singapore General Hospital, Singapore, Singapore.
Ronnie MathewDepartment of Colorectal Surgery, Singapore General Hospital, Singapore, Singapore.
Melissa TeoDivision of Surgical Oncology, National Cancer Centre Singapore (NCCS), Singapore, Singapore.
Wan Teck LimDivision of Medical Oncology, National Cancer Centre Singapore (NCCS), Singapore, Singapore.
Chee Keong TohDivision of Medical Oncology, National Cancer Centre Singapore (NCCS), Singapore, Singapore.
Boon-Hean OngDepartment of Cardiothoracic Surgery, National Heart Centre Singapore (NHCS), Singapore, Singapore.
Tina KohDivision of Surgical Oncology, National Cancer Centre Singapore (NCCS), Singapore, Singapore.
Axel M HillmerAgency for Science, Technology and Research (A*STAR), Genome Institute of Singapore (GIS), Singapore, Singapore.
Angela TakanoDepartment of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore.
Tony Kiat Hon LimDepartment of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore.
Eng Huat TanDivision of Medical Oncology, National Cancer Centre Singapore (NCCS), Singapore, Singapore.
Weiwei ZhaiAgency for Science, Technology and Research (A*STAR), Genome Institute of Singapore (GIS), Singapore, Singapore.
Daniel S W TanDivision of Medical Oncology, National Cancer Centre Singapore (NCCS), Singapore, Singapore.
Iain Beehuat TanDivision of Medical Oncology, National Cancer Centre Singapore (NCCS), Singapore, Singapore.
Evan W NewellAgency for Science, Technology and Research (A*STAR), Singapore Immunology Network (SIgN), Singapore, Singapore. evan_newell@immunol.a-star.edu.sg.
Agency for Science, Technology and Research · SGNational Cancer Centre Singapore · SGGenome Institute of Singapore · SGSingapore General Hospital · SGSingapore Immunology Network · SGNational Heart Centre Singapore · SG
Funding
No grant is acknowledged in the PubMed record.
Abstract
Various forms of immunotherapy, such as checkpoint blockade immunotherapy, are proving to be effective at restoring T cell-mediated immune responses that can lead to marked and sustained clinical responses, but only in some patients and cancer types
Indexed as
Antigens, NeoplasmAntigens, ViralApyraseBystander EffectCD8-Positive T-LymphocytesCell SeparationColorectal NeoplasmsErbB ReceptorsHumansLung NeoplasmsLymphocytes, Tumor-InfiltratingPhenotypeAntigens, NeoplasmAntigens, ViralApyraseENTPD1 protein, humanErbB Receptors
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.