ArticleNature2018
RSPO2 inhibition of RNF43 and ZNRF3 governs limb development independently of LGR4/5/6.
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Nature, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 107 papers.
0numbers the graph read from it
0cells of the map it votes in
107citing papers in PubMed
10.0field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
107 citing papers in PubMed, 193 citations in OpenAlex.
- Human trilayer engineered blood vessel reveals influence of fibroblasts on disease progression in model of Hutchinson-Gilford progeria.Science advances · 2026Article
- Lgr6Genes & diseases · 2026Review
- Genomic signatures of selection reveal genetic mechanisms underlying economic traits in Licha black pigs.Animal bioscience · 2026Article
- Loss of ZNRF3/RNF43 unleashes EGFR in cancer.eLife · 2026Article
- The m6Am methyltransferase PCIF1 promotes osteogenic differentiation of mesenchymal stem cells through stabilization of Wnt-related transcripts.PLoS biology · 2026Article
- RSPO2-induced ferroptosis via PTBP1-mediated FSP1 mRNA decay suppresses breast cancer progression.Frontiers in oncology · 2026Article
- Plasma R-spondin 2 levels are associated with the progression of diabetic kidney disease.Frontiers in endocrinology · 2026Article
- Targeting Wnt/β-catenin signaling enhances the efficacy of anti-CD38 immunotherapy in multiple myeloma.Neoplasia (New York, N.Y.) · 2025Article
- Wnt induces FZD5/8 endocytosis and degradation and the involvement of RSPO-ZNRF3/RNF43 and DVL.eLife · 2025Article
- The RSPO2 gene is associated with bilateral anterior amelia in Chihuahuas.Mammalian genome : official journal of the International Mammalian Genome Society · 2025Article
- Article
- Gustatory-neuron-supplied R-spondin-2 is required for taste bud replenishment.Stem cell reports · 2025Article
- WNT signaling coordinately controls mouse limb bud outgrowth and establishment of the digit-interdigit pattern.Development (Cambridge, England) · 2025Article
- Mechanistic insights into Wnt-β-catenin pathway activation and signal transduction.Nature reviews. Molecular cell biology · 2025Review
- Article
- LGR4 (GPR48): The Emerging Inter-Bridge in Osteoimmunology.Biomedicines · 2025Review
- TheFrontiers in medicine · 2025Review
- A novel variation inFrontiers in pediatrics · 2025Article
- Article
- Deleterious ZNRF3 germline variants cause neurodevelopmental disorders with mirror brain phenotypes via domain-specific effects on Wnt/β-catenin signaling.American journal of human genetics · 2024Article
47 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
27 authors at 12 institutions in 8 countries.
Emmanuelle Szenker-Ravi *Institute of Medical Biology, A*STAR, Singapore, Singapore.
Umut Altunoglu *Medical Genetics Department, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey.
Marc Leushacke *Institute of Medical Biology, A*STAR, Singapore, Singapore.
Célia Bosso-LefèvreInstitute of Medical Biology, A*STAR, Singapore, Singapore.
Muznah KhatooInstitute of Medical Biology, A*STAR, Singapore, Singapore.
Hong Thi TranDepartment of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.
Thomas NaertDepartment of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.
Rivka NoelandersDepartment of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.
Amin HajamohideenInstitute of Medical Biology, A*STAR, Singapore, Singapore.
Claire BeneteauCHU Nantes, Service de Génétique Médicale, Nantes, France.
Sergio B de SousaMedical Genetics Unit, Hospital Pediátrico, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.
Birsen KaramanMedical Genetics Department, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey.
Xenia LatypovaCHU Nantes, Service de Génétique Médicale, Nantes, France.
Seher BaşaranMedical Genetics Department, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey.
Esra Börklü YücelMedical Genetics Department, Koç University School of Medicine (KUSOM), Istanbul, Turkey.
Thong Teck TanInstitute of Medical Biology, A*STAR, Singapore, Singapore.
Lena VlaminckDepartment of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.
Shalini S NayakDepartment of Medical Genetics, Kasturba Medical College, Manipal University, Manipal, India.
Anju ShuklaDepartment of Medical Genetics, Kasturba Medical College, Manipal University, Manipal, India.
Katta Mohan GirishaDepartment of Medical Genetics, Kasturba Medical College, Manipal University, Manipal, India.
Cédric Le CaignecCHU Nantes, Service de Génétique Médicale, Nantes, France.
Natalia SoshnikovaInstitute of Molecular Biology (IMB) gGmbH, Mainz, Germany.
Zehra Oya UygunerMedical Genetics Department, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey.
Kris VleminckxDepartment of Biomedical Molecular Biology, Ghent University, Ghent, Belgium. kris.vleminckx@irc.ugent.be.
Nick BarkerInstitute of Medical Biology, A*STAR, Singapore, Singapore. nicholas.barker@imb.a-star.edu.sg.
Hülya KayseriliMedical Genetics Department, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey. hkayserili@kuh.ku.edu.tr.
Bruno ReversadeInstitute of Medical Biology, A*STAR, Singapore, Singapore. bruno@reversade.com.
Agency for Science, Technology and Research · SGGhent University · BEIstanbul University · TRGénétique Médicale & Génomique Fonctionelle · FRInstitute of Medical Biology · SGKasturba Medical College, Manipal · INKoç University · TRInstitute of Molecular Biology · DEKanazawa University · JPManipal Academy of Higher Education · INUniversité Bretagne Loire · FRUniversity of Coimbra · PT
Funding
No grant is acknowledged in the PubMed record.
Abstract
The four R-spondin secreted ligands (RSPO1-RSPO4) act via their cognate LGR4, LGR5 and LGR6 receptors to amplify WNT signalling
Indexed as
AnimalsDNA-Binding ProteinsExtremitiesFemaleFibroblastsGene Knockout TechniquesHEK293 CellsHumansIntercellular Signaling Peptides and ProteinsLimb Deformities, CongenitalMaleMiceOncogene ProteinsPhenotypeReceptors, G-Protein-CoupledR-SpondinsDNA-Binding ProteinsIntercellular Signaling Peptides and ProteinsLGR4 protein, humanLGR5 protein, humanLGR6 protein, humanOncogene ProteinsReceptors, G-Protein-CoupledRNF43 protein, humanRspo2 protein, humanR-SpondinsUbiquitin-Protein LigasesZNRF3 protein, human
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.