ArticleScientific reports2018
Maternal supraphysiological hypercholesterolemia associates with endothelial dysfunction of the placental microvasculature.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 48 citations in OpenAlex.
- Leptin-cholesterol crosstalk in pregnancy: Mechanistic implications for placental function and cardiometabolic programming.Experimental physiology · 2026Review
- MaterLIP clinical trial design: extra virgin olive oil supplementation in pregnancies with increased cholesterol levels.BMC pregnancy and childbirth · 2026Article
- Association between maternal personality traits and fetal atherogenic indices: a cross-sectional study.BMC pregnancy and childbirth · 2026Article
- Early pregnancy maternal lipid profile, acute phase responders, and the association with preterm delivery and selected pregnancy outcomes.Pregnancy (Hoboken, N.J.) · 2025Article
- Ex vivo myo-mechanical assessment of isolated rectus abdominis muscle in pregnancy-specific urinary incontinence: a cross-sectional study nested within the Diamater cohort.Biomedical engineering online · 2025Article
- Comparative analysis of lipid metabolism in trophoblast subpopulations in preeclampsia andFrontiers in molecular biosciences · 2025Article
- Evidence for hypoxia-induced dysregulated cholesterol homeostasis in preeclampsia: Insights into the mechanisms from human placental cells and tissues.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Article
- Maternal Supraphysiological Hypercholesterolemia Is Accompanied by Shifts in the Composition and Anti-Atherogenic Functions of Maternal HDL along with Maternal Cardiovascular Risk Markers at Term of Pregnancy.Antioxidants (Basel, Switzerland) · 2023Article
- Association between maternal cholesterol level during pregnancy and placental weight and birthweight ratio: data from the Japan Environment and Children's Study.BMC pregnancy and childbirth · 2023Article
- Expression of ABCA1 Transporter and LXRA/LXRB Receptors in Placenta of Women with Late Onset Preeclampsia.Journal of clinical medicine · 2022Article
- Primary Human Trophoblasts Mimic the Preeclampsia Phenotype after Acute Hypoxia-Reoxygenation Insult.Cells · 2022Article
- Increased Circulating Levels of PCSK9 and Pro-Atherogenic Lipoprotein Profile in Pregnant Women with Maternal Supraphysiological Hypercholesterolemia.Antioxidants (Basel, Switzerland) · 2022Article
- Trophoblast Differentiation Affects Crucial Nutritive Functions of Placental Membrane Transporters.Frontiers in cell and developmental biology · 2022Article
- An Overview of Vascular Dysfunction and Determinants: The Case of Children of African Ancestry.Frontiers in pediatrics · 2021Review
- Maternal cholesterol levels during gestation: boon or bane for the offspring?Molecular and cellular biochemistry · 2021Review
- Cholesterol uptake and efflux are impaired in human trophoblast cells from pregnancies with maternal supraphysiological hypercholesterolemia.Scientific reports · 2020Article
- Article
- Placental secretion of apolipoprotein A1 and E: the anti-atherogenic impact of the placenta.Scientific reports · 2019Article
- Lipid Profile Pattern among Women Screened for Hyperglycaemia in Pregnancy at the University of Jos Teaching Hospital, Nigeria.Nigerian medical journal : journal of the Nigeria Medical AssociationArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Maternal physiological or supraphysiological hypercholesterolemia (MPH, MSPH) occurs during pregnancy. MSPH is associated with foetal endothelial dysfunction and atherosclerosis. However, the potential effects of MSPH on placental microvasculature are unknown. The aim of this study was to determine whether MSPH alters endothelial function in the placental microvasculature both ex vivo in venules and arterioles from the placental villi and in vitro in primary cultures of placental microvascular endothelial cells (hPMEC). Total cholesterol < 280 mg/dL indicated MPH, and total cholesterol ≥280 mg/dL indicated MSPH. The maximal relaxation to histamine, calcitonin gene-related peptide and adenosine was reduced in MSPH venule and arteriole rings. In hPMEC from MSPH placentas, nitric oxide synthase (NOS) activity and L-arginine transport were reduced without changes in arginase activity or the protein levels of endothelial NOS (eNOS), human cationic amino acid 1 (hCAT-1), hCAT-2A/B or arginase II compared with hPMEC from MPH placentas. In addition, it was shown that adenosine acts as a vasodilator of the placental microvasculature and that NOS is active in hPMEC. We conclude that MSPH alters placental microvascular endothelial function via a NOS/L-arginine imbalance. This work also reinforces the concept that placental endothelial cells from the macro- and microvasculature respond differentially to the same pathological condition.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.