Evidence map›Paper›PMID 29769701›Full record

ArticleScientific reports2018

A Drosophila Model of Essential Tremor.

Philip Smith, Ronald Arias, Shilpa Sonti, Zagaa Odgerel, Ismael Santa-Maria, Brian D McCabe, Krasimira Tsaneva-Atanasova, Elan D Louis, James J L Hodge, Lorraine N Clark

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Sleep regulation inFrontiers in neuroscience · 2026
    Review
  3. Understanding and Treating Niemann-Pick Type C Disease: Models Matter.International journal of molecular sciences · 2020
    Review
  4. Article
  5. Review
  6. Etiologic links between environmental and lifestyle factors and Essential tremor.Annals of clinical and translational neurology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Philip SmithSchool of Physiology, Pharmacology and Neuroscience, University of Bristol, University Walk, Bristol, BS8 1TD, UK.
Ronald AriasDepartment of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA.
Shilpa SontiDepartment of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA.
Zagaa OdgerelDepartment of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA.
Ismael Santa-MariaDepartment of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA.
Brian D McCabeBrain Mind Institute, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.ORCID 0000-0003-1620-0501
Krasimira Tsaneva-AtanasovaDepartment of Mathematics and Living Systems Institute, University of Exeter, Stocker Road, Exeter, EX4 4QD, UK.ORCID 0000-0002-6294-7051
Elan D LouisDepartment of Neurology, Yale School of Medicine, Yale University, New Haven, CT, 06520, USA.
James J L HodgeSchool of Physiology, Pharmacology and Neuroscience, University of Bristol, University Walk, Bristol, BS8 1TD, UK. james.hodge@bristol.ac.uk.
Lorraine N ClarkDepartment of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA. lc654@columbia.edu.
Columbia University · USUniversity of Bristol · GBÉcole Polytechnique Fédérale de Lausanne · CHEngineering and Physical Sciences Research Council · GBYale University · US

Funding

Identification of Susceptibility Genes for Essential TremorR01NS073872 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CLARK, LORRAINE N, LOUIS, ELAN D · 2011 to 2019
$7.4M
MicroRNA modulation of tau expression and phosphorylation in tauopathyR01NS095922 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SANTA-MARIA PEREZ, ISMAEL · 2016 to 2020
$2.0M
Biotechnology and Biological Sciences Research Council BB/J014400/1NINDS NIH HHS R01 NS073872NINDS NIH HHS R01 NS095922
6 · The paper itself

Abstract

Essential Tremor (ET) is one of the most common neurological diseases, with an estimated 7 million affected individuals in the US; the pathophysiology of the disorder is poorly understood. Recently, we identified a mutation (KCNS2 (Kv9.2), c.1137 T > A, p.(D379E) in an electrically silent voltage-gated K

Indexed as

Models, NeurologicalMutationAdultAlgorithmsAnimalsAnimals, Genetically ModifiedBehavior, AnimalBrainDrosophila melanogasterEssential TremorFemaleHumansIon Channel GatingMalePotassium Channels, Voltage-GatedSleep Wake DisordersKCNS2 protein, humanPotassium Channels, Voltage-Gated

Identifiers

PMID29769701
PMCPMC5955955
OpenAlexW2804577908

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.