ArticleScientific reports2018
Elevated plasma lipoprotein(a) levels were associated with increased risk of cardiovascular events in Chinese patients with stable coronary artery disease.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Prognostic value of lipoprotein (a) level in patients with coronary artery disease: a meta-analysis.Lipids in health and disease · 2019Pooled it
- Association of skeletal muscle index and intermuscular adipose tissue index measured by non-contrast chest CT with major adverse cardiovascular events in patients with coronary artery disease: a nested case-control study in a Chinese population.Frontiers in cardiovascular medicine · 2026Article
- Leveraging pleiotropic clustering to address high proportion correlated horizontal pleiotropy in Mendelian randomization studies.Nature communications · 2025Article
- Downregulation of microRNA‑221‑3p promotes angiogenesis of lipoprotein(a)‑injured endothelial progenitor cells by targeting silent information regulator 1 to activate the RAF/MEK/ERK signaling pathway.Molecular medicine reports · 2024Article
- Plasma tissue-type plasminogen activator is associated with lipoprotein(a) and clinical outcomes in hospitalized patients with COVID-19.Research and practice in thrombosis and haemostasis · 2023Article
- Alterations of NMR-Based Lipoprotein Profile Distinguish Unstable Angina Patients with Different Severity of Coronary Lesions.Metabolites · 2023Article
- Polymorphisms of the 11q23.3 Locus Affect the Risk and Mortality of Coronary Artery Disease.Journal of clinical medicine · 2022Article
- Association between Social Support and Physical Activity in Patients with Coronary Artery Disease: Multiple Mediating Roles of Self-Efficacy and Autonomous Motivation.Healthcare (Basel, Switzerland) · 2022Article
- Polymorphisms of LPA gene, rs1801693 and rs7765781, are not associated with premature myocardial infarction in the Iranian population.ARYA atherosclerosis · 2021Article
- Lipoprotein(a) levels and risk of abdominal aortic aneurysm in the Women's Health Initiative.Journal of vascular surgery · 2021Article
- Elevated lipoprotein(a) and risk of coronary heart disease according to different lipid profiles in the general Chinese community population: the CHCN-BTH study.Annals of translational medicine · 2021Article
- Coronary Artery Disease: Optimal Lipoprotein(a) for Survival-Lower Is Better? A Large Cohort With 43,647 Patients.Frontiers in cardiovascular medicine · 2021Article
- Association between plasma betaine levels and dysglycemia in patients with coronary artery disease.Bioscience reports · 2020Article
- Article
- The association of serum total bile acid with non-alcoholic fatty liver disease in Chinese adults: a cross sectional study.Lipids in health and disease · 2020Article
- The Association of Syntax Score with Levels of Lipoprotein(a) and Inflammatory Biomarkers in Patients with Stable Coronary Artery Disease and Different Low-Density Lipoprotein Cholesterol Levels.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Association of lipoprotein(a) and major adverse cardiovascular events in patients with percutaneous coronary intervention.Archives of medical science : AMS · 2019Article
- Elevated lipoprotein (a) levels are associated with the acute myocardial infarction in patients with normal low-density lipoprotein cholesterol levels.Bioscience reports · 2019Observational
- Higher serum lectin-like oxidized low-density lipoprotein receptor-1 in patients with stable coronary artery disease is associated with major adverse cardiovascular events: A multicentre pilot study.Biochemia medica · 2019Observational
- Baseline levels of serum high sensitivity C reactive protein and lipids in predicting the residual risk of cardiovascular events in Chinese population with stable coronary artery disease: a prospective cohort study.Lipids in health and disease · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies have suggested that lipoprotein(a) [Lp(a)] is associated with cardiovascular disease (CVD). However, the contribution of Lp(a) to residual risk of CVD has not been determined in Chinese populations. We conducted a prospective study to evaluate the association between Lp(a) and the risk of major adverse cardiovascular events (MACEs) in patients with stable coronary artery disease (CAD) who received optimal medication treatment (OMT). The study enrolled 1602 patients with stable CAD from 5 hospitals in China. The baseline clinical characteristics and follow-up MACE data for the patients were recorded. Coronary lesion severity was assessed by the Gensini scoring system. All-cause death, non-fatal myocardial infarction, non-fatal stroke and unplanned coronary revascularization were considered MACEs. We found that plasma Lp(a) levels were positively associated with coronary lesion severity at baseline (p < 0.001). During a mean follow-up period of 39.6 months, 166 (10.4%) patients suffered MACEs. There were significant differences in the adjusted event-free survival rates among the Lp(a) quartile subgroups (p = 0.034). The hazard ratio for MACEs was 1.291 (95% confidence interval: 1.091-1.527, p = 0.003) per standardized deviation in the log-transformed Lp(a) level after adjustment for traditional cardiovascular risk factors. Therefore, Lp(a) was an independent predictor of MACEs in Chinese patients with stable CAD who received OMT.
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