ArticleScientific reports2018
High-speed Fourier ptychographic microscopy based on programmable annular illuminations.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Fast full-color pathological imaging via an optimized illumination pattern with color transfer in Fourier ptychographic microscopy (OIP-CTFPM).Biomedical optics express · 2026Article
- Fourier ptychographic coherence scanning interferometry for 3D morphology of high aspect ratio and composite micro-trenches.Light, science & applications · 2026Article
- Digital Holographic Microscopy for Phenotypic Profiling of Adherent Cells.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Metasurface-based Fourier ptychographic microscopy.Nanophotonics (Berlin, Germany) · 2025Article
- Enhancing classification of rare white blood cells in FPM with a physics-inspired GAN.Scientific reports · 2025Article
- High-throughput marker-free screening of cytoplasmic vacuoles in adherent cells via Fourier ptychographic microscopy.Biomedical optics express · 2025Article
- Electron fourier ptychography for phase reconstruction.Scientific reports · 2025Article
- ST-FPM: suppressor tunable FPM for high-quality and highly robust full-field reconstruction.Biomedical optics express · 2025Article
- Uncertainty-aware Fourier ptychography.Light, science & applications · 2025Article
- Fast Fourier ptychographic microscopy based on annular illumination and parallel acquisition.Biomedical optics express · 2025Article
- Classifying breast cancer and fibroadenoma tissue biopsies from paraffined stain-free slides by fractal biomarkers in Fourier Ptychographic Microscopy.Computational and structural biotechnology journal · 2024Article
- Quantitative phase imaging based on holography: trends and new perspectives.Light, science & applications · 2024Review
- Ultra-high spatio-temporal resolution imaging with parallel acquisition-readout structured illumination microscopy (PAR-SIM).Light, science & applications · 2024Article
- Spatially-coded Fourier ptychography: flexible and detachable coded thin films for quantitative phase imaging with uniform phase transfer characteristics.Advanced optical materials · 2024Article
- Multi-scale fractal Fourier Ptychographic microscopy to assess the dose-dependent impact of copper pollution on living diatoms.Scientific reports · 2024Article
- Review
- On the use of deep learning for phase recovery.Light, science & applications · 2024Review
- Fast Fourier ptychographic quantitative phase microscopy for in vitro label-free imaging.Biomedical optics express · 2024Article
- Roadmap on computational methods in optical imaging and holography [invited].Applied physics. B, Lasers and optics · 2024Review
- Fast and robust Fourier ptychographic microscopy with position misalignment correction.Journal of biomedical optics · 2023Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High-throughput quantitative phase imaging (QPI) is essential to cellular phenotypes characterization as it allows high-content cell analysis and avoids adverse effects of staining reagents on cellular viability and cell signaling. Among different approaches, Fourier ptychographic microscopy (FPM) is probably the most promising technique to realize high-throughput QPI by synthesizing a wide-field, high-resolution complex image from multiple angle-variably illuminated, low-resolution images. However, the large dataset requirement in conventional FPM significantly limits its imaging speed, resulting in low temporal throughput. Moreover, the underlying theoretical mechanism as well as optimum illumination scheme for high-accuracy phase imaging in FPM remains unclear. Herein, we report a high-speed FPM technique based on programmable annular illuminations (AIFPM). The optical-transfer-function (OTF) analysis of FPM reveals that the low-frequency phase information can only be correctly recovered if the LEDs are precisely located at the edge of the objective numerical aperture (NA) in the frequency space. By using only 4 low-resolution images corresponding to 4 tilted illuminations matching a 10×, 0.4 NA objective, we present the high-speed imaging results of in vitro Hela cells mitosis and apoptosis at a frame rate of 25 Hz with a full-pitch resolution of 655 nm at a wavelength of 525 nm (effective NA = 0.8) across a wide field-of-view (FOV) of 1.77 mm
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Registered trials
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