ArticleScientific reports2018
Effectiveness of in-Line Filters to Completely Remove Particulate Contamination During a Pediatric Multidrug Infusion Protocol.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 33 citations in OpenAlex.
- Strategies for Assessing Physical Compatibility of Calcium Folinate with Bicarbonate During Methotrexate Rescue Therapy in Pediatric Patients with Acute Lymphoblastic Leukemia.Pharmaceutics · 2025Article
- Evaluation of the Impact of Infusion Set Design on the Particulate Load Induced by Vancomycin-Piperacillin/Tazobactam Incompatibility.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Visible particles in parenteral drug products: A review of current safety assessment practice.Current research in toxicology · 2024Article
- Evaluation of Strategies for Reducing Vancomycin-Piperacillin/Tazobactam Incompatibility.Pharmaceutics · 2023Article
- Nursing strategies for the mechanically ventilated patient.Frontiers in veterinary science · 2023Review
- Multidisciplinary Approach to Deciphering Etoposide Infusion Reactions and Potential Role of Polyethersulfone Filter Membranes.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2023Article
- A large amount of microscopic precipitates are inevitably injected during infusion therapy without an in-line filter.Oxford medical case reports · 2022Article
- Strategies to prevent drug incompatibility during simultaneous multi-drug infusion in intensive care units: a literature review.European journal of clinical pharmacology · 2021Review
- Optimising an Infusion Protocol Containing Cefepime to Limit Particulate Load to Newborns in a Neonatal Intensive Care Unit.Pharmaceutics · 2021Article
- Pharmaceutical Quality of Selected Metronidazole and Ciprofloxacin Infusions Marketed in South Eastern Nigeria.Drug, healthcare and patient safety · 2020Article
- In-line filtration of intravenous infusion may reduce organ dysfunction of adult critical patients.Critical care (London, England) · 2019Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The large number of drugs administered simultaneously to neonates and children in hospital results in the formation of particles that are potentially infused. We have investigated the ability of IV in-line filters to eliminate particulate matter from multidrug infusion lines and so prevent contamination. The impact on particle occurrence of the internal volume of the IV line below the in-line filter was then evaluated. The multidrug therapy given to children was reproduced with and without in-line filtration. Three combinations with a filter were tested to vary the internal volume (V) between the filter and the catheter egress. The catheter was then connected to a dynamic particle count to evaluate the particulate matter potentially administered to children during infusion. The introduction of in-line filters led to a significant reduction in overall particulate matter, from 416,974 [208,479-880,229] to 7,551 [1,985-11,287] particles (p < 0.001). Larger particles of ≥10 and 25 µm were also significantly reduced. Adding an extension set to the egress of the in-line filter (V = 1.7 mL) caused a significant increase in particulate contamination for both. This study showed that in-line filtration is an effective tool in preventing particle administration to patients. Their position in the infusion in-line is therefore important because of its impact on internal volume and drug particle formation.
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