ArticleNature communications2018
Myosin1D is an evolutionarily conserved regulator of animal left-right asymmetry.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- In vivo modeling of lethal congenital contracture syndrome 1 suggests pathomechanisms in cellular stress responses.The FEBS journal · 2025Article
- Myosin 15 participates in assembly and remodeling of the presynapse.The Journal of cell biology · 2025Article
- Epithelial cell chirality emerges through the dynamic concentric pattern of actomyosin cytoskeleton.eLife · 2025Article
- Left-right symmetry breaking: learning from the chicken.Frontiers in cell and developmental biology · 2025Review
- Breaking Left-Right Symmetry by the Interplay of Planar Cell Polarity, Calcium Signaling and Cilia.Cells · 2024Review
- Contributions of the Dachsous intracellular domain to Dachsous-Fat signaling.Development (Cambridge, England) · 2024Article
- Myosin1G promotes Nodal signaling to control zebrafish left-right asymmetry.Nature communications · 2024Article
- Identification of a novel MYO1D variant associated with laterality defects, congenital heart diseases, and sperm defects in humans.Frontiers of medicine · 2024Article
- Biomechanical Modeling of Cell Chirality and Symmetry Breaking of Biological Systems.Mechanobiology in medicine · 2024Article
- Functional analysis of germline VANGL2 variants using rescue assays of vangl2 knockout zebrafish.Human molecular genetics · 2024Article
- Pathway to Independence: the future of developmental biology.Development (Cambridge, England) · 2023Article
- Chiral growth of adherent filopodia.Biophysical journal · 2023Article
- Fluid extraction from the left-right organizer uncovers mechanical properties needed for symmetry breaking.eLife · 2023Article
- A spatiotemporal barrier formed by Follistatin is required for left-right patterning.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Asymmetric activity of NetrinB controls laterality of the Drosophila brain.Nature communications · 2023Article
- Multiple pkd and piezo gene family members are required for atrioventricular valve formation.Nature communications · 2023Article
- The genetic landscape of cardiovascular left-right patterning defects.Current opinion in genetics & development · 2022Review
- Sequential action of JNK genes establishes the embryonic left-right axis.Development (Cambridge, England) · 2022Article
- LUBAC regulates ciliogenesis by promoting CP110 removal from the mother centriole.The Journal of cell biology · 2022Article
- Understanding laterality disorders and the left-right organizer: Insights from zebrafish.Frontiers in cell and developmental biology · 2022Review
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The establishment of left-right (LR) asymmetry is fundamental to animal development, but the identification of a unifying mechanism establishing laterality across different phyla has remained elusive. A cilia-driven, directional fluid flow is important for symmetry breaking in numerous vertebrates, including zebrafish. Alternatively, LR asymmetry can be established independently of cilia, notably through the intrinsic chirality of the acto-myosin cytoskeleton. Here, we show that Myosin1D (Myo1D), a previously identified regulator of Drosophila LR asymmetry, is essential for the formation and function of the zebrafish LR organizer (LRO), Kupffer's vesicle (KV). Myo1D controls the orientation of LRO cilia and interacts functionally with the planar cell polarity (PCP) pathway component VanGogh-like2 (Vangl2), to shape a productive LRO flow. Our findings identify Myo1D as an evolutionarily conserved regulator of animal LR asymmetry, and show that functional interactions between Myo1D and PCP are central to the establishment of animal LR asymmetry.
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