Evidence map›Paper›PMID 29769406›Full record

ArticleMolecular cancer research : MCR2018

Spindle Assembly Disruption and Cancer Cell Apoptosis with a CLTC-Binding Compound.

Michael J Bond, Marina Bleiler, Lauren E Harrison, Eric W Scocchera, Masako Nakanishi, Narendran G-Dayanan, Santosh Keshipeddy, Daniel W Rosenberg, Dennis L Wright, Charles Giardina

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular cancer research : MCR, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Polydatin: A natural compound with multifaceted anticancer properties.Journal of traditional and complementary medicine · 2025
    Review
  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Michael J BondDepartment of Molecular and Cell Biology, University of Connecticut, Storrs, Connecticut.
Marina BleilerDepartment of Molecular and Cell Biology, University of Connecticut, Storrs, Connecticut.ORCID 0000-0003-2256-589X
Lauren E HarrisonDepartment of Molecular and Cell Biology, University of Connecticut, Storrs, Connecticut.ORCID 0000-0002-7727-4873
Eric W ScoccheraDepartment of Medicinal Chemistry, University of Connecticut, Storrs, Connecticut.
Masako NakanishiCenter for Molecular Oncology, UConn Health, Farmington, Connecticut.
Narendran G-DayananDepartment of Medicinal Chemistry, University of Connecticut, Storrs, Connecticut.
Santosh KeshipeddyDepartment of Medicinal Chemistry, University of Connecticut, Storrs, Connecticut.
Daniel W RosenbergCenter for Molecular Oncology, UConn Health, Farmington, Connecticut.
Dennis L WrightDepartment of Medicinal Chemistry, University of Connecticut, Storrs, Connecticut.
Charles GiardinaDepartment of Molecular and Cell Biology, University of Connecticut, Storrs, Connecticut. charles.giardina@uconn.edu.
University of Connecticut · USUConn Health · US

Funding

(1) Intestinal Organoid Models for APC LOHR21CA208638 · NCI · UNIVERSITY OF CONNECTICUT STORRS · PI GIARDINA, CHARLES A. · 2016 to 2017
$425k
NCI NIH HHS R21 CA208638
6 · The paper itself

Abstract

AK3 compounds are mitotic arrest agents that induce high levels of γH2AX during mitosis and apoptosis following release from arrest. We synthesized a potent AK3 derivative, AK306, that induced arrest and apoptosis of the HCT116 colon cancer cell line with an EC

Indexed as

AnimalsApoptosisClathrin Heavy ChainsColonic NeoplasmsGene Knockdown TechniquesHCT116 CellsHumansMaleMiceMitosisMolecular Targeted TherapyPiperazinesSpindle ApparatusStructure-Activity RelationshipTransfection(4-(3-chlorophenyl)piperazin-1-yl)(2-ethoxyphenyl)methanoneClathrin Heavy ChainsCLTC protein, humanPiperazines

Identifiers

PMID29769406
PMCPMC6125173
OpenAlexW2804447970

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.