ArticleBMJ (Clinical research ed.)2018
Role of obesity in smoking behaviour: Mendelian randomisation study in UK Biobank.
Article in BMJ (Clinical research ed.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers, 9 of them syntheses that pooled it.
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Who cites it
102 citing papers in PubMed, 9 syntheses or guidelines pooled it.
- Strengthening the reporting of observational studies in epidemiology using Mendelian randomization (STROBE-MR): a Korean translation of explanation and elaboration.Ewha medical journal · 2025Guideline
- The Relationship Between Paternal Smoking and Overweight/Obesity with Childhood Overweight/Obesity: A Systematic Review.Current obesity reports · 2025Pooled it
- Polygenic scores for tobacco use provide insights into systemic health risks in a diverse EHR-linked biobank in Los Angeles.Translational psychiatry · 2024Pooled it
- Causal effects from tobacco smoking initiation on obesity-related traits: a Mendelian randomization study.International journal of obesity (2005) · 2023Pooled it
- Maternal Cigarette Smoking and Cleft Lip and Palate: A Systematic Review and Meta-Analysis.The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association · 2022Pooled it
- Body Mass Index and the Risk of Atrial Fibrillation: A Mendelian Randomization Study.Nutrients · 2022Pooled it
- Body mass index and colorectal cancer risk: A Mendelian randomization study.Cancer science · 2021Pooled it
- Cross-cancer evaluation of polygenic risk scores for 16 cancer types in two large cohorts.Nature communications · 2021Pooled it
- Obesity paradox in subarachnoid hemorrhage: a systematic review.Neurosurgical review · 2020Pooled it
- Genetic evidence against a causal relationship between myocardial infarction and urological malignancies.The Canadian journal of urology · 2026Article
- Pre-diagnostic body mass index trajectories and associations with lung cancer risk.American journal of epidemiology · 2026Article
- Associations of lifestyle behaviors with overweight and obesity: a cross-sectional study in Shenzhen, China.Frontiers in nutrition · 2026Article
- Genetically modeled GLP1R and GIPR agonism reduce binge drinking and alcohol-associated phenotypes: a multi-ancestry drug-target Mendelian randomization study.Molecular psychiatry · 2025Article
- Reassessing the link between adiposity and head and neck cancer: a Mendelian randomization study.eLife · 2025Article
- Evaluating the interrelationship of mindfulness, sexual relational concern, and health related behaviors on women's life satisfaction through path analysis.BMC women's health · 2025Article
- Impact of socioeconomic status on obesity in older adults: the suppressive effect of social support and sleep quality.BMC geriatrics · 2025Article
- Causal association of obesity and chronic pain mediated by educational attainment and smoking: a mediation Mendelian randomization study.The Korean journal of pain · 2025Article
- A focusing framework for testing bi-directional causal effects in Mendelian randomization.Journal of the Royal Statistical Society. Series B, Statistical methodology · 2025Article
- Evaluation of pregnancy outcomes in patients with a history of bariatric surgery.Frontiers in medicine · 2025Article
- Article
42 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors.
Funding
Abstract
objectiveTo determine whether body mass index, body fat percentage, and waist circumference influence smoking status and intensity.
designMendelian randomisation study.
settingUK Biobank, with replication of results from the Tobacco and Genetics (TAG) consortium.
participantsEuropean descent participants from the UK Biobank cohort (n=372 791) and the TAG consortium (n=74 035).
main outcome measuresRisk of current and past smoking, number of cigarettes smoked per day, age of smoking initiation.
resultsThe Mendelian randomisation analysis indicated that each standard deviation increment in body mass index (4.6) increased the risk of being a smoker (odds ratio 1.18 (95% confidence interval 1.13 to 1.23), P<0.001). This association was replicated in the TAG consortium data (1.19 (1.06 to 1.33), P=0.003). Furthermore, each standard deviation increment in body mass index was estimated to increase smoking intensity by 0.88 cigarettes per day (95% confidence interval 0.50 to 1.26, P<0.001) in UK Biobank and 1.27 cigarettes per day in the TAG consortium (0.46 to 2.07, P=0.002). Similar results were also seen for body fat percentage and waist circumference in both UK Biobank and the TAG consortium data.
conclusionsThese results strongly suggest that higher adiposity influences smoking behaviour and could have implications for the implementation of public health interventions aiming to reduce the prevalence of these important risk factors.
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