Evidence map›Paper›PMID 29769337›Full record

ArticleJournal of virology2018

Entry of Herpes Simplex Virus 1 into Epidermis and Dermal Fibroblasts Is Independent of the Scavenger Receptor MARCO.

Katharina Thier, Maureen Möckel, Katja Palitzsch, Katinka Döhner, Beate Sodeik, Dagmar Knebel-Mörsdorf

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Eczema Herpeticum: Clinical and Pathophysiological Aspects.Clinical reviews in allergy & immunology · 2020
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Katharina ThierCenter for Biochemistry, University of Cologne, Cologne, Germany.
Maureen MöckelCenter for Biochemistry, University of Cologne, Cologne, Germany.
Katja PalitzschCenter for Biochemistry, University of Cologne, Cologne, Germany.
Katinka DöhnerInstitute of Virology, Hannover Medical School, Hannover, Germany.
Beate SodeikInstitute of Virology, Hannover Medical School, Hannover, Germany.
Dagmar Knebel-MörsdorfCenter for Biochemistry, University of Cologne, Cologne, Germany dagmar.moersdorf@uni-koeln.de.
University of Cologne · DEMedizinische Hochschule Hannover · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To enter host cells, herpes simplex virus 1 (HSV-1) initially attaches to cell surface glycosaminoglycans, followed by the requisite binding to one of several cellular receptors, leading to viral internalization. Although virus-receptor interactions have been studied in various cell lines, the contributions of individual receptors to uptake into target tissues such as mucosa, skin, and cornea are not well understood. We demonstrated that nectin-1 acts as a major receptor for HSV-1 entry into murine epidermis, while herpesvirus entry mediator (HVEM) can serve as an alternative receptor. Recently, the macrophage receptor with collagenous structure (MARCO) has been described to mediate adsorption of HSV-1 to epithelial cells. Here, we investigated the impact of MARCO on the entry process of HSV-1 into the two major cell types of skin, keratinocytes in the epidermis and fibroblasts in the underlying dermis. Using

Indexed as

Virus InternalizationAnimalsDermisEpidermisFibroblastsHerpesvirus 1, HumanHumansKeratinocytesMiceMice, KnockoutReceptors, ImmunologicMARCO protein, humanMarco protein, mouseReceptors, Immunologicdermal fibroblastsentry receptorepidermisherpesvirusesHSV-1keratinocytesMARCOskinSR-A1SR-A6

Identifiers

PMID29769337
PMCPMC6052305
OpenAlexW2804199761

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.