Evidence map›Paper›PMID 29769331›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Temporal transcriptional logic of dynamic regulatory networks underlying nitrogen signaling and use in plants.

Kranthi Varala, Amy Marshall-Colón, Jacopo Cirrone, Matthew D Brooks, Angelo V Pasquino, Sophie Léran, Shipra Mittal, Tara M Rock, Molly B Edwards, Grace J Kim and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed, 1 pooled it
31.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

105 citing papers in PubMed, 1 synthesis or guideline pooled it, 212 citations in OpenAlex.

  1. Pooled it
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  12. Antagonistic regulation of nitrogen and drought signaling mediated by NIN-like protein 7 transcription factor inProceedings of the National Academy of Sciences of the United States of America · 2026
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45 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 2 countries.

Kranthi VaralaHorticulture and Landscape Architecture/Center for Plant Biology, Purdue University, West Lafayette, IN 47907.
Amy Marshall-ColónDepartment of Plant Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801.
Jacopo CirroneCourant institute for Mathematical Sciences, New York University, New York, NY 10012.
Matthew D BrooksCenter for Genomics and Systems Biology, Department of Biology, New York University, New York, NY 10003.
Angelo V PasquinoCenter for Genomics and Systems Biology, Department of Biology, New York University, New York, NY 10003.
Sophie LéranCenter for Genomics and Systems Biology, Department of Biology, New York University, New York, NY 10003.
Shipra MittalCenter for Genomics and Systems Biology, Department of Biology, New York University, New York, NY 10003.
Tara M RockCenter for Genomics and Systems Biology, Department of Biology, New York University, New York, NY 10003.
Molly B EdwardsCenter for Genomics and Systems Biology, Department of Biology, New York University, New York, NY 10003.
Grace J KimCenter for Genomics and Systems Biology, Department of Biology, New York University, New York, NY 10003.
Sandrine RuffelLaboratoire de Biochimie et Physiologie Moléculaire des Plantes, UMR CNRS/INRA/SupAgro/Université Montpellier, Montpellier 34060, France.
W Richard McCombieCold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724.
Dennis ShashaCourant institute for Mathematical Sciences, New York University, New York, NY 10012.
Gloria M CoruzziCenter for Genomics and Systems Biology, Department of Biology, New York University, New York, NY 10003; gloria.coruzzi@nyu.edu.ORCID 0000-0003-2608-2166
New York University · USCourant Institute of Mathematical Sciences · USCentre National de la Recherche Scientifique · FRCold Spring Harbor Laboratory · USPurdue University West Lafayette · USUniversity of Illinois Urbana-Champaign · US

Funding

REGULATION OF AMINO ACID BIOSYNTHESIS GENES IN PLANTSR01GM032877 · NIGMS · ROCKEFELLER UNIVERSITY · PI CORUZZI, GLORIA · 1985 to 2012
$4.8M
Arabidopsis N-regulatory network dynamics: Integrating metabolome & transcriptomeF32GM095273 · NIGMS · NEW YORK UNIVERSITY · PI MARSHALL COLON, AMY J · 2010 to 2012
$153k
Uncovering the molecular basis for dynamic regulatory networks in plantsF32GM116347 · NIGMS · NEW YORK UNIVERSITY · PI BROOKS, MATTHEW D · 2016 to 2017
$121k
NIGMS NIH HHS F32 GM095273NIGMS NIH HHS F32 GM116347NIGMS NIH HHS R01 GM032877
6 · The paper itself

Abstract

This study exploits time, the relatively unexplored fourth dimension of gene regulatory networks (GRNs), to learn the temporal transcriptional logic underlying dynamic nitrogen (N) signaling in plants. Our "just-in-time" analysis of time-series transcriptome data uncovered a temporal cascade of

Indexed as

ArabidopsisArabidopsis ProteinsGene Expression ProfilingGene Expression Regulation, PlantGene Regulatory NetworksLogicNitrogenProtein BindingSignal TransductionTranscription FactorsTranscription, GeneticArabidopsis ProteinsNitrogenTranscription Factorsnetwork inferencenitrogen assimilationplant biologysystems biologytranscriptional dynamics

Identifiers

PMID29769331
PMCPMC6016767
OpenAlexW2803763306

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.