Evidence map›Paper›PMID 29769325›Full record

ArticlePlant physiology2018

The Ancient Phosphatidylinositol 3-Kinase Signaling System Is a Master Regulator of Energy and Carbon Metabolism in Algae.

Rishiram Ramanan, Quynh-Giao Tran, Dae-Hyun Cho, Jae-Eun Jung, Byung-Hyuk Kim, Sang-Yoon Shin, Sae-Hae Choi, Kwang-Hyeon Liu, Dae-Soo Kim, Seon-Jin Lee and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in Plant physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Evolutionary conservation and metabolic significance of autophagy in algae.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024
    Review
  4. Article
  5. The MicroalgaPlant physiology · 2020
    Article
  6. Article
  7. Interplay Between Lipid Metabolism and Autophagy.Frontiers in cell and developmental biology · 2020
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 4 countries.

Rishiram RamananDepartment of Environmental Science, School of Earth Science Systems, Central University of Kerala, Tejaswini Hills, Periya, Kasaragod 671316, Kerala, India.ORCID 0000-0002-4641-9603
Quynh-Giao TranCell Factory Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Yuseong-gu, Daejeon 34141, Republic of Korea.
Dae-Hyun ChoCell Factory Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Yuseong-gu, Daejeon 34141, Republic of Korea.
Jae-Eun JungGenome Research Center, KRIBB, Yuseong-gu, Daejeon 34141, Republic of Korea.ORCID 0000-0001-5179-4603
Byung-Hyuk KimCell Factory Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Yuseong-gu, Daejeon 34141, Republic of Korea.
Sang-Yoon ShinCell Factory Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Yuseong-gu, Daejeon 34141, Republic of Korea.
Sae-Hae ChoiCell Factory Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Yuseong-gu, Daejeon 34141, Republic of Korea.
Kwang-Hyeon LiuCollege of Pharmacy, Kyungpook National University, Daegu 41566, Republic of Korea.ORCID 0000-0002-3285-5594
Dae-Soo KimGenome Research Center, KRIBB, Yuseong-gu, Daejeon 34141, Republic of Korea.
Seon-Jin LeeBiomedical Genomics Research Center, KRIBB, Yuseong-gu, Daejeon 34141, Republic of Korea.
José L CrespoInstituto de Bioquimica Vegetal y Fotosintesis, Consejo Superior de Investigaciones Cientificas, Universidad de Sevilla, Seville 41092, Spain.ORCID 0000-0003-3514-1025
Hee-Gu LeeBiomedical Genomics Research Center, KRIBB, Yuseong-gu, Daejeon 34141, Republic of Korea.
Hee-Mock OhCell Factory Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Yuseong-gu, Daejeon 34141, Republic of Korea.ORCID 0000-0002-2151-3687
Hee-Sik KimCell Factory Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Yuseong-gu, Daejeon 34141, Republic of Korea hkim@kribb.re.kr.ORCID 0000-0002-9500-5394
Korea Research Institute of Bioscience and Biotechnology · KRGenome Research Foundation · KRGenomics Medicine (Ireland) · IECentral University of Kerala · INConsejo Superior de Investigaciones Científicas · ESKyungpook National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Algae undergo a complete metabolic transformation under stress by arresting cell growth, inducing autophagy and hyper-accumulating biofuel precursors such as triacylglycerols and starch. However, the regulatory mechanisms behind this stress-induced transformation are still unclear. Here, we use biochemical, mutational, and "omics" approaches to demonstrate that PI3K signaling mediates the homeostasis of energy molecules and influences carbon metabolism in algae. In

Indexed as

Adenosine TriphosphateAutophagyCarbonChlamydomonas reinhardtiiEnergy MetabolismEnzyme InhibitorsGene Knockdown TechniquesLipid MetabolismMembrane LipidsMutationPhosphatidylinositol 3-KinasesPhosphoinositide-3 Kinase InhibitorsPhylogenyPlant ProteinsScenedesmusSignal TransductionAdenosine TriphosphateCarbonEnzyme InhibitorsMembrane LipidsPhosphatidylinositol 3-KinasesPhosphoinositide-3 Kinase InhibitorsPlant ProteinsStarch

Identifiers

PMID29769325
PMCPMC6053016
OpenAlexW2804052534

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.