Evidence map›Paper›PMID 29769321›Full record

ArticleThe Journal of biological chemistry2018

Lectin-mediated binding and sialoglycans of porcine surfactant protein D synergistically neutralize influenza A virus.

Martin van Eijk, Michael J Rynkiewicz, Kshitij Khatri, Nancy Leymarie, Joseph Zaia, Mitchell R White, Kevan L Hartshorn, Tanya R Cafarella, Irma van Die, Martin Hessing and 2 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. The Aging Human Lung Mucosa: A Proteomics Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Innate Immunity and Influenza A Virus Pathogenesis: Lessons for COVID-19.Frontiers in cellular and infection microbiology · 2020
    Review
  11. Why Glycosylation Matters in Building a Better Flu Vaccine.Molecular & cellular proteomics : MCP · 2019
    Review
  12. Article
  13. Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Martin van EijkFrom the Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, 3584 CL Utrecht, The Netherlands, m.vaneijk@uu.nl.
Michael J Rynkiewiczthe Departments of Physiology and Biophysics and.
Kshitij KhatriCenter for Biomedical Mass Spectrometry, Boston University School of Medicine, Boston, Massachusetts 02118.ORCID 0000-0002-6592-869X
Nancy LeymarieCenter for Biomedical Mass Spectrometry, Boston University School of Medicine, Boston, Massachusetts 02118.
Joseph ZaiaCenter for Biomedical Mass Spectrometry, Boston University School of Medicine, Boston, Massachusetts 02118.ORCID 0000-0001-9497-8701
Mitchell R WhiteMedicine, and.
Kevan L HartshornMedicine, and.
Tanya R Cafarellathe Departments of Physiology and Biophysics and.
Irma van Diethe Department of Molecular Cell Biology and Immunology, VU University Medical Center, 1081 HZ Amsterdam, The Netherlands, and.
Martin Hessingthe U-Protein Express B.V., Life Science Incubator, Utrecht Science Park, Yalelaan 62, 3584CM Utrecht, The Netherlands.
Barbara A Seatonthe Departments of Physiology and Biophysics and.
Henk P HaagsmanFrom the Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, 3584 CL Utrecht, The Netherlands.
Boston University · USUtrecht University · NLAmsterdam UMC Location Vrije Universiteit Amsterdam · NLProtein Express (United States) · US

Funding

Structural Basis of Immune Recognition of Glycosylated AntigensU54GM062116 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI SASISEKHARAN, RAM · 2001 to 2010
$80.3M
Mass Spectrometry Resource for Biology and MedicineP41GM104603 · NIGMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI COSTELLO, CATHERINE E. · 2012 to 2017
$10.4M
Enhancing Collectin-Mediated Defense Against InfluenzaR01HL069031 · NHLBI · BOSTON MEDICAL CENTER · PI HARTSHORN, KEVAN L · 2002 to 2018
$6.6M
Collectins and Innate Defense against Inhaled PathogensP01AI083222 · NIAID · BOSTON UNIVERSITY MEDICAL CAMPUS · PI SEATON, BARBARA A · 2009 to 2010
$4.9M
Legacy Support During Closure of the Mass Spectrometry Resource for Biology and MedicineR24GM134210 · NIGMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI COSTELLO, CATHERINE E. · 2019 to 2021
$2.1M
An open-source software suite for processing glycomics and glycoproteomics mass spectral dataU01CA221234 · NCI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ZAIA, JOSEPH · 2017 to 2019
$1.2M
MALDI-TOF/TOF MS TO SUPPORT BIOMEDICAL RESEARCHS10OD010724 · OD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI COSTELLO, CATHERINE E. · 2012 to 2012
$590k
NCI NIH HHS U01 CA221234NHLBI NIH HHS R01 HL069031NIAID NIH HHS P01 AI083222NIGMS NIH HHS P41 GM104603NIGMS NIH HHS R24 GM134210NIGMS NIH HHS U54 GM062116NIH HHS S10 OD010724
6 · The paper itself

Abstract

Innate immunity is critical in the early containment of influenza A virus (IAV) infection, and surfactant protein D (SP-D) plays a crucial role in the pulmonary defense against IAV. In pigs, which are important intermediate hosts during the generation of pandemic IAVs, SP-D uses its unique carbohydrate recognition domain (CRD) to interact with IAV. An

Indexed as

Amino Acid SequenceAnimalsBinding SitesCarbohydrate ConformationGlycosylationHemagglutination Inhibition TestsImmunity, InnateInfluenza A virusLectinsOrthomyxoviridae InfectionsPolysaccharidesPulmonary Surfactant-Associated Protein DSequence HomologySialic AcidsSwineLectinsPolysaccharidesPulmonary Surfactant-Associated Protein DSialic Acidsantiviral agentcollectindrug designhost–pathogen interactioninfluenza virusinnate immunityN-linked glycosylationporcine immunologypulmonary defenserecombinant proteinsialic acidstructural biologysurfactant protein Dviral immunology

Identifiers

PMID29769321
PMCPMC6036198
OpenAlexW2803533771

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.