Evidence map›Paper›PMID 29769292›Full record

ArticleG3 (Bethesda, Md.)2018

A Genome-Wide Assay Specifies Only GreA as a Transcription Fidelity Factor in

Charles C Traverse, Howard Ochman

Open access · goldAbstract read
In one paragraph

Article in G3 (Bethesda, Md.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
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  9. Autoregulation ofInternational journal of molecular sciences · 2019
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Charles C TraverseDepartment of Integrative Biology, University of Texas, Austin, Texas 78712.
Howard OchmanDepartment of Integrative Biology, University of Texas, Austin, Texas 78712 howard.ochman@austin.utexas.edu.ORCID 0000-0003-1688-7059
The University of Texas at Austin · US

Funding

Elucidating the Evolution of Microbial Genes, Genomes and CommunitiesR35GM118038 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI OCHMAN, HOWARD · 2016 to 2025
$4.0M
Elucidating a newly discovered selective agent operating in bacterial genomesR01GM108657 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI OCHMAN, HOWARD · 2014 to 2016
$824k
The impact of transcription quality control mechanisms on transcriptional errorsF31GM122275 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI TRAVERSE, CHARLES C · 2017 to 2018
$39k
NIGMS NIH HHS F31 GM122275NIGMS NIH HHS R01 GM108657NIGMS NIH HHS R35 GM118038
6 · The paper itself

Abstract

Although mutations are the basis for adaptation and heritable genetic change, transient errors occur during transcription at rates that are orders of magnitude higher than the mutation rate. High rates of transcription errors can be detrimental by causing the production of erroneous proteins that need to be degraded. Two transcription fidelity factors, GreA and GreB, have previously been reported to stimulate the removal of errors that occur during transcription, and a third fidelity factor, DksA, is thought to decrease the error rate through an unknown mechanism. Because the majority of transcription-error assays of these fidelity factors were performed

Indexed as

Gene Expression Regulation, BacterialGenomicsTranscription, GeneticEscherichia coliEscherichia coli ProteinsMutationTranscription FactorsEscherichia coli ProteinsGreA protein, E coliTranscription FactorsE. colifidelity factorsgreAmutationstranscription errors

Identifiers

PMID29769292
PMCPMC6027873
OpenAlexW2803832775

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.