Evidence map›Paper›PMID 29769279›Full record

ArticleJournal of clinical microbiology2018

Microbial Interactions in the Cystic Fibrosis Airway.

Ann M Granchelli, Frederick R Adler, Ruth H Keogh, Christiana Kartsonaki, David R Cox, Theodore G Liou

Open access · bronzeAbstract read
In one paragraph

Article in Journal of clinical microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 62 citations in OpenAlex.

  1. Review
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  14. Frontiers in cellular and infection microbiology · 2024
    Article
  15. Article
  16. Pathogenesis ofInfection and immunity · 2023
    Article
  17. Article
  18. Article
  19. A guide toFrontiers in cellular and infection microbiology · 2023
    Review
  20. Biofilm Formation byInternational journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Ann M GranchelliThe Adult Cystic Fibrosis Center, Division of Respiratory, Critical Care and Occupational Pulmonary Medicine, Department of Internal Medicine, University of Utah, Salt Lake City, Utah, USA.
Frederick R AdlerCenter for Quantitative Biology, University of Utah, Salt Lake City, Utah, USA.
Ruth H KeoghLondon School of Hygiene and Tropical Medicine, London, United Kingdom.
Christiana KartsonakiNuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.
David R CoxNuffield College, Oxford, United Kingdom.
Theodore G LiouThe Adult Cystic Fibrosis Center, Division of Respiratory, Critical Care and Occupational Pulmonary Medicine, Department of Internal Medicine, University of Utah, Salt Lake City, Utah, USA ted.liou@utah.edu.ORCID 0000-0003-0121-4847
University of Utah · USLondon School of Hygiene & Tropical Medicine · GBUniversity of Oxford · GB

Funding

Project 2: Targeting Cooperative Phenotypes Common in Spatial HeterogeneityU54CA209978 · NCI · UNIVERSITY OF UTAH · PI MOOS, PHILIP J · 2017 to 2021
$10.5M
Multidisciplinary Pulmonary and Critical Care Training ProgramT32HL105321 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Ramsey Hachem, Robert Paine · 2010 to 2026
$4.5M
Explanatory models of CF Survival, Infection and Intermediate Clinical OutcomesR01HL125520 · NHLBI · UNIVERSITY OF UTAH · PI LIOU, THEODORE GEH-LU · 2015 to 2018
$1.4M
Medical Research Council MR/M014827/1NCI NIH HHS U54 CA209978NHLBI NIH HHS R01 HL125520NHLBI NIH HHS T32 HL105321
6 · The paper itself

Abstract

Interactions in the airway ecology of cystic fibrosis may alter organism persistence and clinical outcomes. Better understanding of such interactions could guide clinical decisions. We used generalized estimating equations to fit logistic regression models to longitudinal 2-year patient cohorts in the Cystic Fibrosis Foundation Patient Registry, 2003 to 2011, in order to study associations between the airway organisms present in each calendar year and their presence in the subsequent year. Models were adjusted for clinical characteristics and multiple observations per patient. Adjusted models were tested for sensitivity to cystic fibrosis-specific treatments. The study included 28,042 patients aged 6 years and older from 257 accredited U.S. care centers and affiliates. These patients had produced sputum specimens for at least two consecutive years that were cultured for methicillin-sensitive

Indexed as

Microbial InteractionsMicrobiotaAdolescentBacteriaChildCystic FibrosisFemaleFungiHumansLongitudinal StudiesMaleRespiratory Tract InfectionsSputumYoung Adultairway infectionsBurkholderiacystic fibrosislogistic regressionmicrobial ecologyPseudomonas aeruginosaStaphylococcus aureus

Identifiers

PMID29769279
PMCPMC6062800
OpenAlexW2803287442

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.