ArticleJournal of immunology (Baltimore, Md. : 1950)2018
Genome-Wide Posttranscriptional Dysregulation by MicroRNAs in Human Asthma as Revealed by Frac-seq.
Article in Journal of immunology (Baltimore, Md. : 1950), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Integrated transcriptomic analysis identifies tsRNA-mRNA regulatory axis in asthma pathogenesis.The World Allergy Organization journal · 2026Article
- Airway epithelial dysfunction in asthma pathogenesis: epigenetic mechanisms, inflammatory crosstalk, and therapeutic opportunities.Frontiers in allergy · 2026Review
- Association of theBiology of sport · 2024Article
- The RNA binding proteinsFrontiers in cell and developmental biology · 2023Article
- Role of airway epithelial cell miRNAs in asthma.Frontiers in allergy · 2022Review
- Metabolites of intestinal microflora upregulate microRNA-200c-3p expression level to suppress airway epithelial inflammation via the IL6ST/JNK/STAT3 signaling pathway.Experimental and therapeutic medicine · 2021Article
- Dual role of the miR-146 family in rhinovirus-induced airway inflammation and allergic asthma exacerbation.Clinical and translational medicine · 2021Article
- The AI for Scientific Discovery NetworkPatterns (New York, N.Y.) · 2021Review
- MicroRNA Targets for Asthma Therapy.Advances in experimental medicine and biology · 2021Article
- The Effect of Tobacco Smoking and Smoking Cessation on Urinal miRNAs in a Pilot Study.Life (Basel, Switzerland) · 2020Article
- Epigenetic Regulation of Airway Epithelium Immune Functions in Asthma.Frontiers in immunology · 2020Review
- Posttranscriptional Gene Regulatory Networks in Chronic Airway Inflammatory Diseases:Frontiers in immunology · 2020Article
- Review
- Precision medicine and phenotypes, endotypes, genotypes, regiotypes, and theratypes of allergic diseases.The Journal of clinical investigation · 2019Review
- Identification of rare variants of allergic rhinitis based on whole genome sequencing and gene expression profiling: A preliminary investigation in four families.The World Allergy Organization journal · 2019Article
- Reduced expression of miR-146a in human bronchial epithelial cells alters neutrophil migration.Clinical and translational allergy · 2019Article
- Genomic Predictors of Asthma Phenotypes and Treatment Response.Frontiers in pediatrics · 2019Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
MicroRNAs are small noncoding RNAs that inhibit gene expression posttranscriptionally, implicated in virtually all biological processes. Although the effect of individual microRNAs is generally studied, the genome-wide role of multiple microRNAs is less investigated. We assessed paired genome-wide expression of microRNAs with total (cytoplasmic) and translational (polyribosome-bound) mRNA levels employing subcellular fractionation and RNA sequencing (Frac-seq) in human primary bronchoepithelium from healthy controls and severe asthmatics. Severe asthma is a chronic inflammatory disease of the airways characterized by poor response to therapy. We found genes (i.e., isoforms of a gene) and mRNA isoforms differentially expressed in asthma, with novel inflammatory and structural pathophysiological mechanisms related to bronchoepithelium disclosed solely by polyribosome-bound mRNAs (e.g.,
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