Evidence map›Paper›PMID 29769260›Full record

ArticleBlood2018

Bim regulates the survival and suppressive capability of CD8

Kimberle Agle, Benjamin G Vincent, Clint Piper, Ludovic Belle, Vivian Zhou, Warren Shlomchik, Jonathan S Serody, William R Drobyski

Open access · bronzeAbstract read
In one paragraph

Article in Blood, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 44 citations in OpenAlex.

  1. CD8+ Regulatory T Cells.Annual review of immunology · 2026
    Review
  2. Article
  3. CD8Science advances · 2025
    Article
  4. Cytotoxic T Cells: Kill, Memorize, and Mask to Maintain Immune Homeostasis.International journal of molecular sciences · 2025
    Review
  5. Article
  6. Article
  7. Analysis of frequency changes in CD8Diabetology & metabolic syndrome · 2024
    Article
  8. The immunomodulatory effect of oral NaHCOJournal of neuroinflammation · 2024
    Article
  9. An angel or a devil? Current view on the role of CD8Journal of translational medicine · 2024
    Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. The Yin and Yang of Targeting KLRG1Frontiers in immunology · 2022
    Review
  19. Review
  20. CXCR5Journal of immunology (Baltimore, Md. : 1950) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Kimberle AgleDepartment of Medicine, Medical College of Wisconsin, Milwaukee, WI.
Benjamin G VincentDepartment of Microbiology/Immunology and.
Clint PiperDepartment of Medicine, Medical College of Wisconsin, Milwaukee, WI.
Ludovic BelleDepartment of Medicine, Medical College of Wisconsin, Milwaukee, WI.
Vivian ZhouDepartment of Medicine, Medical College of Wisconsin, Milwaukee, WI.
Warren ShlomchikDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA.
Jonathan S SerodyDepartment of Microbiology/Immunology and.
William R DrobyskiDepartment of Medicine, Medical College of Wisconsin, Milwaukee, WI.
Medical College of Wisconsin · USUniversity of North Carolina at Chapel Hill · USUniversity of Pittsburgh · US

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5M
UNC Oncology K12K12CA120780 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WILLIAM Y. KIM · 2007 to 2026
$9.6M
Medical Scientist Training ProgramT32GM080202 · NIGMS · MEDICAL COLLEGE OF WISCONSIN · PI BARBIERI, JOSEPH T, SALZMAN, NITA H · 2010 to 2024
$5.7M
Role of Interleukin 23 in Gastrointestinal GVHDR01HL126166 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI William R. Drobyski · 2015 to 2026
$5.4M
Regulatory T Cell Populations in Graft versus Host DiseaseR01HL064603 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI DROBYSKI, WILLIAM R. · 2000 to 2016
$4.6M
Mechanistic Evaluations of ILC2 Cells for the Treatment/Prevention of GVHDR01HL139730 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SERODY, JONATHAN S. · 2017 to 2020
$2.2M
NCI NIH HHS K12 CA120780NCI NIH HHS P30 CA016086NHLBI NIH HHS R01 HL064603NHLBI NIH HHS R01 HL126166NHLBI NIH HHS R01 HL139730NIGMS NIH HHS T32 GM080202
6 · The paper itself

Abstract

CD8

Indexed as

AnimalsApoptosisBcl-2-Like Protein 11CD8-Positive T-LymphocytesForkhead Transcription FactorsGraft vs Host DiseaseIsoantigensMiceMice, Inbred BALB CMice, Inbred C57BLT-Lymphocytes, RegulatoryBcl2l11 protein, mouseBcl-2-Like Protein 11Forkhead Transcription FactorsFoxp3 protein, mouseIsoantigens

Identifiers

PMID29769260
PMCPMC6071561
OpenAlexW2804877699

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.