Evidence map›Paper›PMID 29769256›Full record

ArticleBMJ open2018

Early use of Antibiotics for at Risk CHildren with InfluEnza (ARCHIE): protocol for a double-blind, randomised, placebo-controlled trial.

Kay Wang, Tricia Carver, Sharon Tonner, Malcolm G Semple, Alastair D Hay, Michael Moore, Paul Little, Christopher Butler, Andrew Farmer, Rafael Perera and 4 more

Open access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 1 country.

Kay WangNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
Tricia CarverNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
Sharon TonnerNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
Malcolm G SempleWomen's and Children's Health, Institute of Translational Medicine, University of Liverpool, Alder Hey Children's Hospital, Liverpool, UK.
Alastair D HayCentre for Academic Primary Care, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Michael MooreAcademic Unit, Primary Care and Population Sciences, University of Southampton, Aldermoor Health Centre, Southampton, UK.
Paul LittleAcademic Unit, Primary Care and Population Sciences, University of Southampton, Aldermoor Health Centre, Southampton, UK.
Christopher ButlerNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
Andrew FarmerNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
Rafael PereraNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
Ly-Mee YuNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.ORCID 0000-0003-0331-7364
Susan MallettInstitute of Applied Health Research, University of Birmingham, Birmingham, UK.
Jane WolstenholmeHealth Economics Research Centre, Nuffield Department of Population Health, Oxford University, Oxford, UK.
Anthony HarndenNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
University of Oxford · GBUniversity of Southampton · GBUniversity of Birmingham · GBUniversity of Bristol · GBUniversity of Liverpool · GB

Funding

Department of Health CDF-2009-02-10Department of Health RP-PG-1210-12012
6 · The paper itself

Abstract

introductionInfluenza and influenza-like illness (ILI) create considerable burden on healthcare resources each winter. Children with pre-existing conditions such as asthma, diabetes mellitus and cerebral palsy are among those at greatest risk of clinical deterioration from influenza/ILI. The Antibiotics for at Risk CHildren with InfluEnza (ARCHIE) trial aims to determine whether early oral treatment with the antibiotic co-amoxiclav reduces the likelihood of reconsultation due to clinical deterioration in these 'at risk' children. METHODS AND ANALYSIS: The ARCHIE trial is a double-blind, parallel, randomised, placebo-controlled trial. 'At risk' children aged 6 months to 12 years inclusive who present within the first 5 days of an ILI episode will be randomised to receive a 5-day course of oral co-amoxiclav 400/57 twice daily or placebo. Randomisation will use a non-deterministic minimisation algorithm to balance age and seasonal influenza vaccination status.To detect respiratory virus infections, a nasal swab will be obtained from each participant before commencing study medication. To identify carriage of potential bacterial respiratory pathogens, we will also obtain a throat swab where possible.The primary outcome is reconsultation in any healthcare setting due to clinical deterioration within 28 days of randomisation. We will analyse this outcome using log-binomial regression model adjusted for region, age and seasonal influenza vaccination status.Secondary outcomes include duration of fever, duration of symptoms and adverse events. Continuous outcomes will be compared using regression analysis (or equivalent non-parametric method for non-normal data) adjusting for minimisation variables. Binary outcomes will be compared using χ ETHICS: The ARCHIE trial has been reviewed and approved by the North West-Liverpool East Research Ethics Committee, Health Research Authority and Medicines and Healthcare Products Regulatory Agency. Our findings will be published in peer-reviewed journals and disseminated via our study website (www.archiestudy.com) and links with relevant charities. TRIAL REGISTRATION NUMBERS: ISRCTN 70714783; Pre-results. EudraCT 2013-002822-21; Pre-results.

Indexed as

Administration, OralAmoxicillin-Potassium Clavulanate CombinationAnti-Bacterial AgentsChildChild, PreschoolDouble-Blind MethodFemaleHumansInfantInfluenza, HumanMaleRandomized Controlled Trials as TopicRegistriesRegression AnalysisTime FactorsTreatment OutcomeAmoxicillin-Potassium Clavulanate CombinationAnti-Bacterial Agentsclinical trialsrespiratory infections

Identifiers

PMID29769256
PMCPMC5961556
OpenAlexW2803159898

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.