SynthesisBMJ open2018
White matter hyperintensities and their subtypes in patients with carotid artery stenosis: a systematic review and meta-analysis.
Synthesis in BMJ open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- White matter hyperintensities and the risk of vascular dementia: a systematic review and meta-analysis.PeerJ · 2025Pooled it
- Relationship between carotid intima-media thickness and white matter hyperintensities in non-stroke adults: a systematic review.Frontiers in neuroanatomy · 2024Pooled it
- Association between intracranial and extracranial atherosclerosis and white matter hyperintensities: a systematic review and meta-analysis.Frontiers in aging neuroscience · 2023Pooled it
- Deep Learning Analysis of White Matter Hyperintensity and its Association with Comprehensive Vascular Factors in Two Large General Populations.Journal of imaging informatics in medicine · 2025Article
- Pathophysiological link between carotid atherosclerosis and cerebral white matter lesions.Scientific reports · 2025Article
- The association of intracranial atherosclerosis with cerebral small vessel disease imaging markers: a high-resolution magnetic resonance imaging study.Scientific reports · 2023Article
- An Investigation of the Relationship Between Carotid Artery Stenosis and White Matter Hyperintensities.Cureus · 2023Article
- Examination of brain area volumes based on voxel-based morphometry and multidomain cognitive impairment in asymptomatic unilateral carotid artery stenosis.Frontiers in aging neuroscience · 2023Article
- The risk factors of old silent brain infarctions in carotid artery stenosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Microstructural Alterations Analogous to Accelerated Aging of the Cerebral Cortex in Carotid Occlusive Disease.Clinical neuroradiology · 2021Article
- Silent brain infarcts and white matter lesions in patients with asymptomatic carotid stenosis.Acta neurologica Belgica · 2021Article
- Subclinical Atherosclerosis, Vascular Risk Factors, and White Matter Alterations in Diffusion Tensor Imaging Findings of Older Adults With Cardiometabolic Diseases.Frontiers in aging neuroscience · 2021Article
- Carotid artery stenosis and brain connectivity: the role of white matter hyperintensities.Neuroradiology · 2020Article
- Completeness of circle of Willis and white matter hyperintensities in patients with severe internal carotid artery stenosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe aimed to perform a systematic review and meta-analysis to clarify the association between white matter hyperintensities (WMHs) and carotid artery (CA) stenosis. STUDY
designSystematic review and meta-analysis.
participantsCA stenosis was set at ≥50%, and WMHs were assessed by MRI and evaluated quantitatively or semiquantitatively. DATA SOURCES: A comprehensive literature search was performed in PubMed, EMBASE and Cochrane Library for studies evaluating the association between WMHs and CA stenosis ≥50% from inception to 13 September 2017. MAIN OUTCOMES AND MEASURES: Standardised mean difference (SMD) with 95% CI was used to evaluate the association between WMHs and CA stenosis. Results were presented in a forest plot with a fixed-effects model or random-effects model. We assessed the quality of included studies using the Newcastle-Ottawa Scale. Funnel plots and Egger's and Begg's tests were conducted to assess publication bias. Sensitivity analysis was performed to evaluate the influence of each individual study.
resultsEight studies enrolling 677 patients were included. There was a positive relationship between the total WMHs and CA stenosis, with a pooled fixed-effects SMD of 0.326 (95% CI 0.194 to 0.459, p=0.000). Heterogeneity and publication bias were low among these studies. Subgroup analysis of three studies enrolling 225 patients showed an association between periventricular WMHs and CA stenosis, with a pooled fixed-effects SMD of 0.412 (95% CI 0.202 to 0.622, p=0.000).
conclusionThis meta-analysis showed that the total WMHs and periventricular WMHs were associated with CA stenosis. WMHs may be considered as an individual risk stratification score when choosing a proper plan for therapy of CA stenosis.
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Registered trials
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