ArticleThe Journal of experimental medicine2018
Spatial distribution and function of T follicular regulatory cells in human lymph nodes.
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Article in The Journal of experimental medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.
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0cells of the map it votes in
77citing papers in PubMed
6.9field-weighted citation impact, top 2% of its field
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Who cites it
77 citing papers in PubMed, 139 citations in OpenAlex.
- Therapeutic potential of targeting Tfr/Tfh cell balance by low-dose-IL-2 in active SLE: a post hoc analysis from a double-blind RCT study.Arthritis research & therapy · 2021Trial
- Regulation of follicular helper T cell subset differentiation in health and disease.Journal of molecular medicine (Berlin, Germany) · 2026Review
- CAR19 Tregs treat murine chronic graft-versus-host disease through immune suppression without measurable B cell cytolysis.JCI insight · 2026Article
- Mixed Signals: T Cells as Architects of IgE Immunity.Immunological reviews · 2026Review
- HIV reservoirs in lymphomagenesis: hidden driver in the era of viral suppression?Microbiology and molecular biology reviews : MMBR · 2025Review
- Multimodal analysis definesbioRxiv : the preprint server for biology · 2025Article
- Intranodal expansion of follicular T helper cells in patients with multiple sclerosis.JCI insight · 2025Article
- Emerging role of follicular regulatory T-cells in neuroimmunological disorders.Current opinion in immunology · 2025Review
- PD-1 and ICOS are coexpressed in T follicular helper cells but define three stages of maturation of T follicular regulatory cells.Science advances · 2025Article
- IL-1β signaling modulates T follicular helper and regulatory cells in human lymphoid tissues.JCI insight · 2025Article
- Increased STAT3 Phosphorylation in CD4Biomedicines · 2025Article
- Methylprednisolone Modulates the Tfr/Tfh ratio in EAE-Induced Neuroinflammation through the PI3K/AKT/FoxO1 and PI3K/AKT/mTOR Signalling Pathways.Inflammation · 2025Article
- PD-1 suppresses human CD38Journal for immunotherapy of cancer · 2025Article
- Natural Compounds fromMedicinal chemistry (Shariqah (United Arab Emirates)) · 2025Article
- Spatial microniches of IL-2 combine with IL-10 to drive lung migratory TNature immunology · 2024Article
- Clinical and prognostic significance of follicular helper and regulatory T cells in bladder cancer draining lymph nodes.Scientific reports · 2024Article
- Spatial technologies to evaluate the HIV-1 reservoir and its microenvironment in the lymph node.mBio · 2024Review
- Article
- IL-12 drives the differentiation of human T follicular regulatory cells.Science immunology · 2024Article
- Multi-omic profiling of follicular lymphoma reveals changes in tissue architecture and enhanced stromal remodeling in high-risk patients.Cancer cell · 2024Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 2 countries.
Ismail SayinDivision of Infectious Diseases and HIV Medicine, Case Western Reserve University, Cleveland, OH.
Andrea J RadtkeLymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD andrea.radtke@nih.gov.
Laura A VellaInstitute for Immunology and Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.ORCID 0000-0002-8917-4845
Wenjie JinDivision of Infectious Diseases and HIV Medicine, Case Western Reserve University, Cleveland, OH.
E John WherryInstitute for Immunology and Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
Marcus BuggertCenter for Infectious Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
Michael R BettsInstitute for Immunology and Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.ORCID 0000-0002-7690-1484
Ramin S HeratiInstitute for Immunology and Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.ORCID 0000-0003-2613-4050
Ronald N GermainLymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.
David H CanadayDivision of Infectious Diseases and HIV Medicine, Case Western Reserve University, Cleveland, OH dxc44@case.edu.ORCID 0000-0001-5503-7888
University of Pennsylvania · USGeriatric Research Education and Clinical Center · USNational Institutes of Health · USKarolinska Institutet · SE
Funding
Clinical and Translational Science Collaborative of ClevelandUL1TR000439 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$50.0MWG3: HIV, Co-infections and Co-morbiditiesP30AI036219 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI Sharon L. Hillier, JONATHAN KARN · 1994 to 2026
$50.0MClinical and Translational Science Collaborative of ClevelandUL1TR002548 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI MCCOMSEY, GRACE A · 2018 to 2022
$35.5MMultiscale Analysis of Immune ResponsesZIAAI000545 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI GERMAIN, RONALD N · 2009 to 2025
$29.4MFunctional Biology Of T CellsZIAAI000758 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI GERMAIN, RONALD N · 2009 to 2025
$15.4MViral control mechanisms of HIV-specific T cells in HIV-infected lymph nodeR01AI118694 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI BETTS, MICHAEL R · 2015 to 2019
$3.3MCD4+ T and B cell mechanisms of influenza vaccine non-responsiveness in older aduR01AI108972 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI BETTS, MICHAEL R, CANADAY, DAVID H · 2014 to 2018
$2.5MEffects of aging on the T follicular helper response to influenza vaccineK08AI114852 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HERATI, RAMIN · 2015 to 2019
$947kNCATS NIH HHS UL1 TR000439NCATS NIH HHS UL1 TR002548NIAID NIH HHS K08 AI114852NIAID NIH HHS P30 AI036219NIAID NIH HHS R01 AI108972NIAID NIH HHS R01 AI118694
Abstract
T follicular regulatory (Tfr) cells are a population of CD4
Indexed as
Antibody FormationAntigens, CDAntigens, Differentiation, T-LymphocyteCD69 AntigensGerminal CenterHumansLectins, C-TypeLymph NodesPhenotypeProgrammed Cell Death 1 ReceptorReceptors, CXCR5T-Lymphocytes, RegulatoryTranscription, GeneticAntigens, CDAntigens, Differentiation, T-LymphocyteCD69 AntigensCXCR5 protein, humanLectins, C-TypePDCD1 protein, humanProgrammed Cell Death 1 ReceptorReceptors, CXCR5
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LicenceCC BY-NC-SA
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.