ArticleDevelopment (Cambridge, England)2018
Size-reduced embryos reveal a gradient scaling-based mechanism for zebrafish somite formation.
Article in Development (Cambridge, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 50 citations in OpenAlex.
- Mitotic Cdc42 waves encode PI(3,4)PScience advances · 2026Article
- Position-dependent feedback drives scaling and robustness of morphogen gradients.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Differential sensitivity of midline development to mitosis during and after primitive streak extension.Developmental dynamics : an official publication of the American Association of Anatomists · 2026Article
- Size-dependent temporal decoupling of morphogenesis and transcriptional programs in pseudoembryos.Science advances · 2025Article
- Formation control between leader and migratory follower tissues allows coordinated growth.Science advances · 2025Article
- Muscle peripheral circadian clock drives nocturnal protein degradation via raised Ror/Rev-erb balance and prevents premature sarcopenia.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Spinal cord elongation enables proportional regulation of the zebrafish posterior body.Development (Cambridge, England) · 2025Article
- Intrinsically robust and scalable biofilm segmentation under diverse physical growth conditions.iScience · 2024Article
- Scale invariance in early embryonic development.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Cell density couples tissue mechanics to control the elongation speed of the body axis.iScience · 2024Article
- Morphogens in the evolution of size, shape and patterning.Development (Cambridge, England) · 2024Review
- Cellular and molecular control of vertebrate somitogenesis.Nature reviews. Molecular cell biology · 2024Review
- Spatiotemporal control of pattern formation during somitogenesis.Science advances · 2024Review
- Scale invariance in early embryonic development.ArXiv · 2023Article
- The evolution of gastrulation morphologies.Development (Cambridge, England) · 2023Review
- Article
- Species-specific roles of the Notch ligands, receptors, and targets orchestrating the signaling landscape of the segmentation clock.Frontiers in cell and developmental biology · 2023Review
- Quantitative Experimental Embryology: A Modern Classical Approach.Journal of developmental biology · 2022Review
- Periodic formation of epithelial somites from human pluripotent stem cells.Nature communications · 2022Article
- Fgf8 dynamics and critical slowing down may account for the temperature independence of somitogenesis.Communications biology · 2022Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
Abstract
Little is known about how the sizes of animal tissues are controlled. A prominent example is somite size, which varies widely both within an individual and across species. Despite intense study of the segmentation clock governing the timing of somite generation, how it relates to somite size is poorly understood. Here, we examine somite scaling and find that somite size at specification scales with the length of the presomitic mesoderm (PSM) despite considerable variation in PSM length across developmental stages and in surgically size-reduced embryos. Measurement of clock period, axis elongation speed and clock gene expression patterns demonstrate that existing models fail to explain scaling. We posit a 'clock and scaled gradient' model, in which somite boundaries are set by a dynamically scaling signaling gradient across the PSM. Our model not only explains existing data, but also makes a unique prediction that we confirm experimentally - the formation of periodic 'echoes' in somite size following perturbation of the size of one somite. Our findings demonstrate that gradient scaling plays a central role in both progression and size control of somitogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.