ArticleClinical cancer research : an official journal of the American Association for Cancer Research2018
Mitigating SOX2-potentiated Immune Escape of Head and Neck Squamous Cell Carcinoma with a STING-inducing Nanosatellite Vaccine.
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In one paragraph
Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
99citing papers in PubMed, 1 pooled it
6.1field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
99 citing papers in PubMed, 1 synthesis or guideline pooled it, 148 citations in OpenAlex.
- Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)Autophagy · 2021Guideline
- IL-1α Expands SLC2A1highSPP1highIFNlow Myeloid Cells to Drive Immune Escape and Malignant Transformation of Precancers.Cancer research · 2026Article
- Targeting KDM3B Elicits Anti-tumor Immunity by Alleviating SHP1-mediated STING Suppression in Triple-Negative Breast Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Therapeutic targeting of the cGAS-STING pathway in human disease.The Journal of clinical investigation · 2026Review
- A biomimetic nanodisc system selectively activates type I interferons by nonclassical STING pathway for cancer immunotherapy.Nature communications · 2026Article
- Precision immunotherapy for head and neck cancer: therapeutic combinations, biomarker strategies, and translational challenges.Molecular cancer · 2026Review
- NLRX1 contributes to immunotherapeutic resistance of head and neck squamous cell carcinoma by suppressing type I interferon pathway.Frontiers in immunology · 2026Article
- BATF2 is a glutamine-responsive tumour suppressor required for type-I interferon-dependent anti-tumour immunity.Nature communications · 2025Article
- Advanced nanotechnology in enhancing immune checkpoint inhibitors (ICIs) for head and neck cancer therapy.Cell communication and signaling : CCS · 2025Review
- Bridging innate and adaptive tumor immunity: cGAS-STING pathway activation to potentiate immune checkpoint blockade.Journal of experimental & clinical cancer research : CR · 2025Review
- cGAS-STING signaling in melanoma: regulation and therapeutic targeting.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Article
- Cancer Cell-Intrinsic Type I Interferon Signaling Promotes Antitumor Immunity in Head and Neck Squamous Cell Carcinoma.Cancers · 2025Article
- The cGAS‒STING pathway in cancer immunity: mechanisms, challenges, and therapeutic implications.Journal of hematology & oncology · 2025Review
- SARS-CoV-2 B Epitope-Guided Neoantigen NanoVaccines Enhance Tumor-Specific CD4/CD8 T Cell Immunity through B Cell Antigen Presentation.ACS nano · 2025Article
- The Role and Mechanism of Innate Immune Regulation in Overcoming Oxaliplatin Resistance and Enhancing Anti-Tumor Efficacy in Colorectal Cancer.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Article
- Mapping immunotherapy potential: spatial transcriptomics in the unraveling of tumor-immune microenvironments in head and neck squamous cell carcinoma.Frontiers in immunology · 2025Review
- Article
- Melanoma vaccines: current R&D landscape, translational hurdles, and future outlook-a perspective drawn from 442 clinical trials.Frontiers in immunology · 2025Review
39 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 6 institutions in 2 countries.
Yee Sun Tan *Department of Periodontics and Oral Medicine, The University of Michigan School of Dentistry, Ann Arbor, Michigan.
Kanokwan Sansanaphongpricha *University of Michigan Rogel Cancer Center, Ann Arbor, Michigan.
Yuying XieDepartment of Computational Mathematics, Science, and Engineering, Michigan State University, East Lansing, Michigan.
Christopher R DonnellyOral Health Sciences PhD Program, The University of Michigan School of Dentistry, Ann Arbor, Michigan.
Xiaobo LuoDepartment of Periodontics and Oral Medicine, The University of Michigan School of Dentistry, Ann Arbor, Michigan.
Blake R HeathDepartment of Periodontics and Oral Medicine, The University of Michigan School of Dentistry, Ann Arbor, Michigan.
Xinyi ZhaoDepartment of Periodontics and Oral Medicine, The University of Michigan School of Dentistry, Ann Arbor, Michigan.
Emily BellileUniversity of Michigan Rogel Cancer Center, Ann Arbor, Michigan.
Hongxiang HuDepartment of Pharmaceutical Sciences, the University of Michigan College of Pharmacy, Ann Arbor, Michigan.
Hongwei ChenDepartment of Pharmaceutical Sciences, the University of Michigan College of Pharmacy, Ann Arbor, Michigan.
Peter J PolveriniDepartment of Periodontics and Oral Medicine, The University of Michigan School of Dentistry, Ann Arbor, Michigan.
Qianming ChenState Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, China.
Simon YoungThe University of Texas Health Science Center at Houston, School of Dentistry, Houston, Texas.
Thomas E CareyUniversity of Michigan Rogel Cancer Center, Ann Arbor, Michigan.
Jacques E NörUniversity of Michigan Rogel Cancer Center, Ann Arbor, Michigan.
Robert L FerrisDepartment of Otolaryngology, University of Pittsburgh Cancer Institute, The University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Gregory T WolfUniversity of Michigan Rogel Cancer Center, Ann Arbor, Michigan.
Duxin SunUniversity of Michigan Rogel Cancer Center, Ann Arbor, Michigan. leiyuleo@med.umich.edu duxins@med.umich.edu.
Yu L LeiDepartment of Periodontics and Oral Medicine, The University of Michigan School of Dentistry, Ann Arbor, Michigan. leiyuleo@med.umich.edu duxins@med.umich.edu.
University of Michigan · USSichuan University · CNMichigan Medicine · USMichigan State University · USThe University of Texas Health Science Center at Houston · USUPMC Hillman Cancer Center · US
Funding
Therapeutic Potential and Mechanism of Action of Potent Small Molecule InhibitorsP50CA097248 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WOLF, GREGORY T · 2002 to 2013
$25.3MRESEARCH TRAINING IN EXPERIMENTAL IMMUNOPATHOLOGYT32AI007413 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Bethany B. Moore · 1993 to 2026
$9.8MRestoring the Immunogenicity of Head and Neck CancerR01DE026728 · NIDCR · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Yu Leo Lei, James J. Moon · 2018 to 2026
$4.3MMolecular Mechanisms of Tumor Behavior and Response to Therapy in HPV-positive Oropharyngeal CancerR01CA194536 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CAREY, THOMAS E. · 2016 to 2021
$2.8MAutophagy-promoting NLRX1-TUFM complex and cancer cell resistance to cetuximabR00DE024173 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LEI, YU LEO · 2016 to 2018
$863kThe Use of Novel Implantable Cancer Vaccines for the Treatment of Oral CancerR00DE023577 · NIDCR · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI YOUNG, SIMON · 2015 to 2017
$747kNCI NIH HHS P50 CA097248NCI NIH HHS R01 CA194536NIAID NIH HHS T32 AI007413NIDCR NIH HHS R00 DE023577NIDCR NIH HHS R00 DE024173NIDCR NIH HHS R01 DE026728
Abstract
PubMed holds no abstract for this paper.
Indexed as
AnimalsAutophagyB7-H1 AntigenCancer VaccinesDrug Resistance, NeoplasmGene Expression Regulation, NeoplasticHEK293 CellsHigh-Throughput Nucleotide SequencingHumansImmune ToleranceImmunotherapyInterferon Type IMembrane ProteinsMiceNanostructuresSOXB1 Transcription FactorsB7-H1 AntigenCancer VaccinesCD274 protein, humanInterferon Type IMembrane ProteinsSOX2 protein, humanSOXB1 Transcription FactorsSTING1 protein, humanSTING Protein
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.