ArticleBMC urology2018
Obesity impairs male fertility through long-term effects on spermatogenesis.
Article in BMC urology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 89 citations in OpenAlex.
- Mouse models of obesity and male fertility: a systematic review and network meta-analysis.Translational andrology and urology · 2026Article
- Obesity Triggers Dysregulation of Essential ABC Transporters in Rat Testis and Sperm.Nutrients · 2026Article
- N-salicyloyl tryptamine derivative ameliorates spermatogenic dysfunction in obese mice by attenuating insulin resistance, enhancing Sertoli cell glycolysis, and inhibiting apoptosis: anFrontiers in cell and developmental biology · 2026Article
- Body fat distribution and semen quality in 4304 Chinese sperm donors.Asian journal of andrology · 2025Article
- Maternal cafeteria diet adversely affects the reproductive parameters of rat offspring in a sex-specific manner.Reproductive biology and endocrinology : RB&E · 2025Article
- Whole tomato lipidic extract improved sperm quality in obese rats induced by a high-carbohydrate diet.Andrology · 2025Article
- Butyrate improves testicular spermatogenic dysfunction induced by a high-fat diet.Translational andrology and urology · 2025Article
- Article
- Effects of Physical Activity on Fertility Parameters: A Meta-Analysis of Randomized Controlled Trials.The world journal of men's health · 2024Article
- 1-DNJ Alleviates Obesity-Induced Testicular Inflammation in Mice Model by Inhibiting IKKβ/ NF-kB Pathway.Reproductive sciences (Thousand Oaks, Calif.) · 2024Article
- Article
- Apocynin Ameliorates Monosodium Glutamate Induced Testis Damage by Impaired Blood-Testis Barrier and Oxidative Stress Parameters.Life (Basel, Switzerland) · 2023Article
- Gut Microbiota-Testis Axis: FMT Mitigates High-Fat Diet-Diminished Male Fertility via Improving Systemic and Testicular Metabolome.Microbiology spectrum · 2022Article
- Effects of whole-life exposure to low-dose cadmium with post-weaning high-fat diet on offspring testes in a male mouse model.Chemico-biological interactions · 2022Article
- Oxidative Stress and Male Infertility: Evidence From a Research Perspective.Frontiers in reproductive health · 2022Review
- Sperm Dysfunction in the Testes and Epididymides due to Overweight and Obesity Is Not Caused by Oxidative Stress.International journal of endocrinology · 2022Article
- Endocrinopathies and Male Infertility.Life (Basel, Switzerland) · 2021Review
- Acetate supplementation restores testicular function by modulating Nrf2/PPAR-γ in high fat diet-induced obesity in Wistar rats.Journal of diabetes and metabolic disorders · 2021Article
- Article
- The Association Between Male Infertility and Cardiometabolic Disturbances: A Population-Based Study.International journal of endocrinology and metabolism · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
objectiveThis study aimed to investigate the effect and possible underlying mechanisms of high-fat diet-induced obesity on spermatogenesis in male rats.
methodsA total of 45 male rats were randomly divided into control (n = 15, normal diet) and obesity groups (n = 30, high-fat diet) and were fed for 16 weeks. Body weight and organ indexes were determined after sacrifice. Indicators of reproductive function, including sperm count, sperm motility, apoptosis of spermatogenic cells, and oxidative stress levels, were measured. Serum metabolic parameters and reproductive hormones were also assayed.
resultsCompared with the control group, epididymal sperm motility in the obese rats was significantly decreased (P < 0.01). Morphological analysis of the obesity group showed vacuolar changes in seminiferous tubules, spermatogenic cell dysfunction, and increased apoptosis of spermatogenic cells in testicular tissue (P < 0.05). The calculated free testosterone (cFT) concentration in serum was decreased (P < 0.05), whereas the serum sex hormone-binding globulin (SHBG) level was significantly increased (P < 0.01). The superoxide dismutase (SOD) concentration decreased and the malondialdehyde (MDA) concentration increased in testis tissues; however, neither changes were statistically significant (P > 0.05).
resultsNutritional obesity can damage spermatogenesis in male rats due to long-term effects on spermatogenesis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.