ArticleBMC complementary and alternative medicine2018
Antimicrobial and antioxidant activities of triterpenoid and phenolic derivatives from two Cameroonian Melastomataceae plants: Dissotis senegambiensis and Amphiblemma monticola.
Article in BMC complementary and alternative medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 68 citations in OpenAlex.
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- Antioxidant and antibacterial activities of the rhizome extract ofJournal of advanced veterinary and animal research · 2023Article
- Structure-dependent activity of plant natural products against methicillin-resistantFrontiers in microbiology · 2023Review
- Phytochemical Analysis, Antifungal, and Antioxidant Properties of Two Herbs (Advances in pharmacological and pharmaceutical sciences · 2023Article
- Major phenolic compounds, antioxidant, antimicrobial, and cytotoxic activities ofFrontiers in nutrition · 2023Article
- Triterpene and Steroids fromEvidence-based complementary and alternative medicine : eCAM · 2023Article
- Characterization of Novel LyticPharmaceuticals (Basel, Switzerland) · 2022Article
- Chemotaxonomy and Antibacterial Activity of the Extracts and Chemical Constituents ofBioMed research international · 2022Article
- Extraction, Profiling, and Characterization of Phytosterols and Triterpenoids from Pili (Biochemistry research international · 2022Article
- Chemopreventive Effect ofMolecules (Basel, Switzerland) · 2021Article
- Antibacterial, antifungal and antioxidant activities of whole plant chemical constituents of Rumex abyssinicus.BMC complementary medicine and therapies · 2021Article
- Antibacterial and Therapeutic Potentials of theBioMed research international · 2021Article
- Review on the Antibacterial Mechanism of Plant-Derived Compounds against Multidrug-Resistant Bacteria (MDR).Evidence-based complementary and alternative medicine : eCAM · 2021Review
- Antimicrobial and Antioxidant Secondary Metabolites fromBioMed research international · 2021Article
- Antibacterial and cytotoxic activities of new sphingolipids and other constituents isolated fromHeliyon · 2020Article
- Terpenoid Esters Are the Major Constituents From Leaf Lipid Droplets ofFrontiers in plant science · 2019Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAntimicrobial resistance is a serious threat against humankind and the search for new therapeutics is needed. This study aims to investigate the antimicrobial and antioxidant activities of ethanol extracts and compounds isolated from Dissotis senegambiensis and Amphiblemma monticola, two Cameroonian Melastomataceae species traditionally used for the treatment of fever, malaria and infectious diseases.
methodsThe plant extracts were prepared by maceration in ethanol. Standard chromatographic and spectroscopic methods were used to isolate and identify fourteen compounds from the two plant species [1-6 (from D. senegambiensis), 3, 4 and 7-14 (from A. monticola)]. A two-fold serial micro-dilution method was used to determine the minimum inhibitory concentration (MIC) against four bacterial strains including two resistant bacterial strains, methicillin resistant S. aureus (MRSA3) and methicillin resistant S. aureus (MRSA4) and three yeast strains.
resultsThe fractionation of EtOH extracts afforded fourteen compounds belonging to triterpenoid and phenolic derivatives. The ethanol extracts, compounds 3, 5-8, 10 and the mixture of 10 + 12 were active against all the tested bacterial and fungal species. Compound 7 (MIC = 16-32 μg/mL) and 10 (MIC = 8-16 μg/mL) displayed the largest antibacterial and antifungal activities, respectively. Compounds 7, 10 and the mixture of 10 + 12 showed prominent antibacterial activity against methicillin- resistant S. aureus (MRSA) which is in some cases equal to that of ciprofloxacin used as reference antibacterial drug. Compound 8 also showed high radical-scavenging activities and ferric reducing power when compared with vitamin C and butylated hydroxytoluene used as reference antioxidants. The tested samples were non-toxic to normal cells highlighting their good selectivity.
conclusionsThe result of this investigation reveals the potential of D. senegambiensis and A. monticola as well as the most active compounds in the search for new antimicrobial and antioxidant agents. So, further investigations are needed.
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