Evidence map›Paper›PMID 29768735›Full record

ReviewMolecular oral microbiology2018

Tobacco-induced suppression of the vascular response to dental plaque.

N Buduneli, D A Scott

Open access · greenAbstract readReview
In one paragraph

Review in Molecular oral microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Tobacco smoke exacerbates Filifactor alocis pathogenicity.Journal of clinical periodontology · 2023
    Article
  14. Review
  15. Review
  16. Article
  17. Review
  18. Review
  19. Article
  20. Self-Perception of Periodontal Health and Associated Factors: A Cross-Sectional Population-Based Study.International journal of environmental research and public health · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

N BuduneliDepartment of Periodontics, School of Dentistry, Ege University, Izmir, Turkey.
D A ScottDepartment of Oral Immunology and Infectious Diseases, School of Dentistry, University of Louisville, Louisville, KY, USA.ORCID 0000-0003-1007-2756
Ege University · TRUniversity of Louisville · US

Funding

Understanding the Host-Microbiome-Therapeutic Triad: Implications for Designing Alternative IntravaginalP20GM125504 · NIGMS · UNIVERSITY OF LOUISVILLE · PI James Tristan Collins · 2018 to 2026
$24.4M
Role of GSK3 in host inflammationR01DE017680 · NIDCR · UNIVERSITY OF LOUISVILLE · PI SCOTT, DAVID A · 2007 to 2017
$3.3M
P. gingivalis genes essential for tobacco smoke survivalR01DE026963 · NIDCR · UNIVERSITY OF LOUISVILLE · PI SCOTT, DAVID A · 2017 to 2024
$2.5M
Tobacco-induced alterations to P. gingivalis-host interactionsR01DE019826 · NIDCR · UNIVERSITY OF LOUISVILLE · PI SCOTT, DAVID A · 2010 to 2014
$1.8M
NIDCR NIH HHS R01 DE017680NIDCR NIH HHS R01 DE019826NIDCR NIH HHS R01 DE026963NIGMS NIH HHS P20 GM125504
6 · The paper itself

Abstract

Cigarette smoking presents oral health professionals with a clinical and research conundrum: reduced periodontal vascular responsiveness to the oral biofilm accompanied by increased susceptibility to destructive periodontal diseases. This presents a significant problem, hampering diagnosis and complicating treatment planning. The aim of this review is to summarize contemporary hypotheses that help to explain mechanistically the phenomenon of a suppressed bleeding response to dysbiotic plaque in the periodontia of smokers. The influence of smoke exposure on angiogenesis, innate cell function, the production of inflammatory mediators including cytokines and proteases, tobacco-bacteria interactions, and potential genetic predisposition are discussed.

Indexed as

AnimalsBacteriaCigarette SmokingCytokinesDental PlaqueGingivaHumansImmunity, InnateModels, AnimalNicotianaPeriodontal DiseasesCytokinesdental plaqueinnate immunityperiodontal diseasestobaccovasculature

Identifiers

PMID29768735
PMCPMC8246627
OpenAlexW2803357168

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.