ArticleAngewandte Chemie (International ed. in English)2018
Enantioselective Synthesis of Chiral Cyclopent-2-enones by Nickel-Catalyzed Desymmetrization of Malonate Esters.
Article in Angewandte Chemie (International ed. in English), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Cobalt-Catalyzed Migratory E-Selective Asymmetric Aza-Nozaki-Hiyama-Kishi Coupling.Angewandte Chemie (International ed. in English) · 2026Article
- Desymmetrization of Malonic Monoesters and Malonic Acids via Enantioselective Catalytic C(spAngewandte Chemie (International ed. in English) · 2026Article
- Iridium-Catalyzed Regio- and Enantioselective Hydrogenation of 5‑Alkylidene Cyclopentenones.Precision chemistry · 2026Article
- Nickel-catalyzed electrophiles-controlled enantioselective reductive arylative cyclization and enantiospecific reductive alkylative cyclization of 1,6-enynes.Nature communications · 2024Article
- Palladium(0)-Catalyzed Anti-Selective Addition-Cyclizations of Alkynyl Electrophiles.Chemistry (Weinheim an der Bergstrasse, Germany) · 2023Article
- Diverse synthesis of α-tertiary amines and tertiary alcohols via desymmetric reduction of malonic esters.Nature communications · 2022Article
- Rapid access toChemical science · 2022Article
- Nickel-Catalyzed Arylative Cyclizations of Alkyne- and Allene-Tethered Electrophiles using Arylboron Reagents.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Review
- Catalytic reductive desymmetrization of malonic esters.Nature chemistry · 2021Article
- Further Developments and Applications of Oxazoline-Containing Ligands in Asymmetric Catalysis.Chemical reviews · 2021Article
- Enantioselective Nickel-Catalyzed anti-Arylmetallative Cyclizations onto Acyclic Ketones.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Stereoselective synthesis of pentasubstituted 1,3-dienesChemical science · 2020Article
- Synthesis of bridged tricyclo[5.2.1.0Nature communications · 2020Article
- Catalytic enantioselective arylative cyclizations of alkynyl 1,3-diketones by 1,4-rhodium(i) migration.Chemical science · 2020Article
- Enantioselective nickel-catalyzed arylative and alkenylative intramolecular 1,2-allylations of tethered allene-ketones.Chemical science · 2020Article
- Enantioselective Synthesis of Chiral Cyclopent-2-enones by Nickel-Catalyzed Desymmetrization of Malonate Esters.Angewandte Chemie (International ed. in English) · 2018Article
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5 authors.
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Abstract
The enantioselective synthesis of highly functionalized chiral cyclopent-2-enones by the reaction of alkynyl malonate esters with arylboronic acids is described. These desymmetrizing arylative cyclizations are catalyzed by a chiral phosphinooxazoline/nickel complex, and cyclization is enabled by the reversible E/Z isomerization of alkenylnickel species. The general methodology is also applicable to the synthesis of 1,6-dihydropyridin-3(2H)-ones.
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