Trial reportJournal of applied oral science : revista FOB2018
Effects of a food enriched with probiotics on Streptococcus mutans and Lactobacillus spp. salivary counts in preschool children: a cluster randomized trial.
Trial report in Journal of applied oral science : revista FOB, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 4 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Effect of probiotic interventions on oral health in children: a systematic review.Frontiers in dental medicine · 2026Pooled it
- The role of probiotics in preventing dental caries: a systematic review of clinical evidence.Frontiers in oral health · 2025Pooled it
- Efficacy of Probiotic Consumption on Oral Outcomes in Children and/or Adolescents: A Meta-Analysis.International dental journal · 2024Pooled it
- Unlocking the potential of probiotic administration in caries management: a systematic review.BMC oral health · 2024Pooled it
- Effects of Probiotic Short-Term Regiment on Oral Health Parameters in Children: A Pilot Randomized Controlled Trial.Nutrients · 2025Trial
- The role of probiotics for preventing dysbiosis in periodontal disease: a randomized controlled trial.Turkish journal of medical sciences · 2024Trial
- Effect of a Short-Term Intervention withInternational journal of environmental research and public health · 2022Trial
- Effects of Oral Probiotics onDentistry journal · 2026Review
- Mechanisms of caries induced by sugars: a narratives review from microbial metabolism to oral ecological imbalance and public health strategies for caries prevention.Frontiers in cellular and infection microbiology · 2026Review
- Review
- The strategic role of biotics in dental caries prevention: A scoping review.Food science & nutrition · 2024Article
- Preventive effects of probiotics on dental caries in vitro and in vivo.BMC oral health · 2024Article
- Effect of Probiotic Supplements on the Oral Microbiota-A Narrative Review.Pathogens (Basel, Switzerland) · 2024Review
- Non-Cariogenic Effect of Milk and Dairy Products on Oral Health in Children and Adolescents: A Scoping Review.Children (Basel, Switzerland) · 2024Article
- A comprehensive review of the application of probiotics and postbiotics in oral health.Frontiers in cellular and infection microbiology · 2023Review
- Effectiveness of probiotic lozenges and Chlorhexidine mouthwash on plaque index, salivary pH, andThe Saudi dental journal · 2021Article
- The Current Strategies in Controlling Oral Diseases by Herbal and Chemical Materials.Evidence-based complementary and alternative medicine : eCAM · 2021Review
- A Review of the Role of Probiotic Supplementation in Dental Caries.Probiotics and antimicrobial proteins · 2020Review
- Effects of a functional food supplemented with probiotics on biological factors related to dental caries in children: a pilot study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2020Article
- Evaluation of the Effect of ProbioticInternational journal of dentistry · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Probiotics have provided benefits to general health, but they are still insufficient to dental health. This study aimed to evaluate milk supplemented with probiotic bacteria and standard milk, measured by levels of Streptococcus mutans (S. mutans) and Lactobacillus spp., in 3-4-year-old children after 9 months of intervention. The study was a triple-blind, placebo-controlled, randomized trial. The sample was composed of 363 preschoolers attending five child development centers in Cali, Colombia. They were randomized to two groups: children in the intervention group drank 200 mL of milk with Lactobacillus rhamnosus 5x106 and Bifidobacteruim longum 3x106, and children in the control group drank 200 mL of standard milk. Interventions occurred on weekdays and information was gathered through scheduled clinical examination. The primary result was the number of colony forming units (CFU) of S. mutans and Lactobacillus spp. in the saliva. Secondary results were dental caries, rated by the International Caries Detection and Assessment System (ICDAS), dental plaque, pH, and salivary buffer capacity. The proportion of S. mutans was lower in the intervention group compared with the control group after 9 months; however, the differences did not reach statistical significance (p=0.173); on the other hand, statistically significant differences between groups were found in the CFU/mL of Lactobacillus spp. (p=0.002). There was not statistically significant difference in the prevalence of dental caries for both groups (p=0.767). Differences between groups were found in the salivary buffering capacity (p=0.000); neither salivary pH nor dental plaque were significantly different. Regular consumption of milk containing probiotics bacteria reduced CFU/mL of Lactobacillus spp. and increased salivary buffering capacity at 9 months of consumption.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.