ArticlePloS one2018
Cytoskeleton structure and total methylation of mouse cardiac and lung tissue during space flight.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Impact of Microgravity on Cytoskeletal Dynamics, Protein Transport, and Signaling Networks: Potential Therapeutic Opportunities for Skin Health.International journal of molecular sciences · 2026Review
- Automated behavioral segmentation and markerless pose tracking of mice during spaceflight.bioRxiv : the preprint server for biology · 2026Article
- Physical exercise protects cardiovascular fitness in long-term spaceflight: what have we learned?Science China. Life sciences · 2026Review
- Aging and Altered Gravity: A Cellular Perspective.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Review
- Transcriptomic Changes in Mouse Lung Tissue after a Long-Term Space Flight.Bulletin of experimental biology and medicine · 2025Article
- Article
- DNA methylation dynamics associated with long-term isolation of simulated space travel.iScience · 2022Article
- Spaceflight Modulates the Expression of Key Oxidative Stress and Cell Cycle Related Genes in Heart.International journal of molecular sciences · 2021Article
- Validation of a New Rodent Experimental System to Investigate Consequences of Long Duration Space Habitation.Scientific reports · 2020Article
- Testes and duct deferens of mice during space flight: cytoskeleton structure, sperm-specific proteins and epigenetic events.Scientific reports · 2019Article
- DNA Methylation of Mouse Testes, Cardiac and Lung Tissue During Long-Term Microgravity Simulation.Scientific reports · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this work was to evaluate the protein and mRNA expression levels of multiple cytoskeletal proteins in the cardiac and lung tissue of mice that were euthanized onboard the United States Orbital Segment of the International Space Station 37 days after the start of the SpaceX-4 mission (September 2014, USA). The results showed no changes in the cytoskeletal protein content in the cardiac and lung tissue of the mice, but there were significant changes in the mRNA expression levels of the associated genes, which may be due to an increase in total genome methylation. The mRNA expression levels of DNA methylases, the cytosine demethylases Tet1 and Tet3, histone acetylase and histone deacetylase did not change, and the mRNA expression level of cytosine demethylase Tet2 was significantly decreased.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.