SynthesisMedicine2018
Lung cancer screening CT-based coronary artery calcification in predicting cardiovascular events: A systematic review and meta-analysis.
Synthesis in Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Structured narrative review on lung cancer screening: current evidence, clinical practice implications and implementation insights from a multidisciplinary task force and patient representatives.European respiratory review : an official journal of the European Respiratory Society · 2025Review
- [Screening, risk stratification and CT imaging for assessment of coronary artery disease].Radiologie (Heidelberg, Germany) · 2024Article
- Advancing Health Equity in Lung Cancer Screening and the Role of Humanomics.Thoracic surgery clinics · 2023Review
- Swiss Pilot Low-Dose CT Lung Cancer Screening Study: First Baseline Screening Results.Journal of clinical medicine · 2023Article
- Opportunistic screening at chest computed tomography: literature review of cardiovascular significance of incidental findings.Cardiovascular diagnosis and therapy · 2023Review
- Reporting Coronary Artery Calcium on Low-Dose Computed Tomography Impacts Statin Management in a Lung Cancer Screening Population.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2022Article
- Effect of Calcification Based on Computer-Aided System on CT-Fractional Flow Reserve in Diagnosis of Coronary Artery Lesion.Computational and mathematical methods in medicine · 2022Article
- Cardiovascular Risk in the Lung Cancer Screening Population: A Multicenter Study Evaluating the Association Between Coronary Artery Calcification and Preventive Statin Prescription.Journal of the American College of Radiology : JACR · 2021Article
- Prediction of Coronary Calcification and Stenosis: Role of Radiomics From Low-Dose CT.Academic radiology · 2021Article
- CT-Detected Subsolid Nodules: A Predictor of Lung Cancer Development at Another Location?Cancers · 2021Article
- Review
- Preoperative coronary artery calcifications in veterans predict higher all-cause mortality in early-stage lung cancer: a cohort study.Journal of thoracic disease · 2021Article
- Recommendations for lung cancer screening in Southern Africa.Journal of thoracic disease · 2019Review
- Early-Stage NSCLC: Advances in Thoracic Oncology 2018.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2019Review
- Lung cancer screening in the gulf: Rationale and recommendations.Annals of thoracic medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCoronary artery calcificition (CAC) is a well-established predictor of cardiovascular events (CVEs). We aimed to evaluate whether lung cancer screening computed tomography (CT)-based CAC score has a good cost-effectiveness for predicting CVEs in heavy smokers.
methodsA literature search was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Pubmed, EMBASE, and Cochrane library databases were systematically searched for relevant studies that investigated the association between lung cancer screening CT-based CAC and CVEs up to December 31, 2017. We selected fixed-effect model for analysis of data heterogeneity. Statistical analyses were performed by using Review Manager Version 5.3 for Windows.
resultsFour randomized controlled trials with 5504 participants were included. Our results demonstrated that CVEs were significantly associated with the presence of CAC (relative risk [RR] 2.85, 95% confidence interval [CI] 2.02-4.02, P < .00001). Moreover, higher CAC score (defined as CAC score >400 or >1000) was associated with a significant increased CVE count (RR 3.47, 95% CI 2.65-4.53, P < .00001). However, the prevalence of CVEs was not different between male and female groups (RR 2.46, 95% CI 0.44-13.66, P = .30).
conclusionCAC Agatston score evaluated by lung cancer screening CT had potential in predicting the likelihood of CVEs in the early stage without sexual difference. Thus, it may guide clinicians to intervene those heavy smokers with increased risk of CVEs earlier by CAC score through lung cancer screening CT.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.