Evidence map›Paper›PMID 29768201›Full record

ArticleCell reports2018

Activation of EphB2 Forward Signaling Enhances Memory Consolidation.

Jessica M Alapin, Monica Dines, Maria Vassiliev, Tal Tamir, Alon Ram, Clifford Locke, Ji Yu, Raphael Lamprecht

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 33 citations in OpenAlex.

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  16. Activity of Insula to Basolateral Amygdala Projecting Neurons is Necessary and Sufficient for Taste Valence Representation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019
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  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Jessica M AlapinSagol Department of Neurobiology, Faculty of Natural Sciences, University of Haifa, Haifa, 3498838, Israel.
Monica DinesSagol Department of Neurobiology, Faculty of Natural Sciences, University of Haifa, Haifa, 3498838, Israel.
Maria VassilievSagol Department of Neurobiology, Faculty of Natural Sciences, University of Haifa, Haifa, 3498838, Israel.
Tal TamirSagol Department of Neurobiology, Faculty of Natural Sciences, University of Haifa, Haifa, 3498838, Israel.
Alon RamSagol Department of Neurobiology, Faculty of Natural Sciences, University of Haifa, Haifa, 3498838, Israel.
Clifford LockeCenter for Cell Analysis and Modeling, University of Connecticut Health Center, Farmington, CT 06030, USA.
Ji YuCenter for Cell Analysis and Modeling, University of Connecticut Health Center, Farmington, CT 06030, USA.
Raphael LamprechtSagol Department of Neurobiology, Faculty of Natural Sciences, University of Haifa, Haifa, 3498838, Israel. Electronic address: rlamp@research.haifa.ac.il.
University of Haifa · ILUConn Health · US

Funding

Super-resolution imaging based on reversible labelingR01GM123784 · NIGMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI YU, JI · 2017 to 2020
$1.3M
NIGMS NIH HHS R01 GM123784
6 · The paper itself

Abstract

EphB2 is involved in enhancing synaptic transmission and gene expression. To explore the roles of EphB2 in memory formation and enhancement, we used a photoactivatable EphB2 (optoEphB2) to activate EphB2 forward signaling in pyramidal neurons in lateral amygdala (LA). Photoactivation of optoEphB2 during fear conditioning, but not minutes afterward, enhanced long-term, but not short-term, auditory fear conditioning. Photoactivation of optoEphB2 during fear conditioning led to activation of the cAMP/Ca

Indexed as

Memory ConsolidationSignal TransductionAmygdalaAnimalsConditioning, ClassicalCyclic AMP Response Element-Binding ProteinFearHEK293 CellsHumansLearningLightMaleMiceMice, Inbred C57BLNIH 3T3 CellsOptogeneticsCyclic AMP Response Element-Binding ProteinPhosphotyrosineReceptor, EphB2src-Family KinasesamygdalaCREBEphB2Eph receptorfear conditioningmemoryOptoEphB2optogenetic

Identifiers

PMID29768201
PMCPMC6314675
OpenAlexW2804663942

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.